AI Article Synopsis
- Accurate and rapid diagnosis is crucial for controlling schistosomiasis, as existing methods like POC-CCA perform poorly in low-endemicity areas.* -
- A new method called POC-CCA filter (FLT) was developed, incorporating a quick urine concentration step that significantly improved diagnostic accuracy in Brazilian endemic areas.* -
- Results showed that POC-CCA FLT had a much higher accuracy rate (up to 100%) compared to the traditional POC-CCA, enhancing its effectiveness in diagnosing cases both before and after treatment.*
Article Abstract
Background: Prior to eliminating schistosomiasis, efforts must address accurate and fast individual diagnosis. Diagnosis is still inaccurate by parasitological and point-of-care circulating cathodic antigen (POC-CCA) in areas of low endemicity.
Methods: Our group has optimized POC-CCA with a 30 min urine concentration step with no need for specialized technicians or equipment and with high accuracy. We evaluated this new method, called POC-CCA filter (FLT), in two Brazilian endemic areas with distinct profiles.
Results: At baseline, POC-CCA had a poor performance with several false results and undefined trace readings, revealing a prevalence rate of 10% against a rate of 23% for POC-CCA FLT, which was similar to the parasitological rates. Accuracy increased from as low as 0.36 to 0.96 after urine concentration in one area. POC-CCA properly diagnosed only half of the cases at three post-treatment time points, while POC-CCA FLT was able to diagnose 96, 83 and 100%, respectively.
Conclusions: The improvement of conventional POC methodology by a fast and simple urine concentration step provided not only an increase in its accuracy before and after praziquantel treatment, but also preserved its applicability in low-prevalence endemic areas, allowing the definition of trace readings as negative cases.
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| http://dx.doi.org/10.1093/trstmh/try014 | DOI Listing |
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