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- This text discusses the treatment of arthritis using conventional medications like corticosteroids and methotrexate, which have significant side effects and costs, while introducing البوليمر المناعي (polyvalent immunoglobulins) as a less commonly used alternative derived from bovine colostrum.* -
- Two male patients with chronic arthritis unresponsive to standard treatments were administered oral polyvalent immunoglobulins, showing rapid pain relief and improvement in one patient’s blood cell count after discontinuing methotrexate.* -
- The results suggest that polyvalent immunoglobulins could effectively reduce inflammation markers and provide a viable treatment option for patients who struggle with traditional therapies.*
[Treatment of multiple sclerosis].
Ned Tijdschr Geneeskd
May 2024
Amsterdam UMC, locatie VUmc, MS Centrum Amsterdam, afd. Neurologie, Amsterdam.
Multiple sclerosis is a chronic inflammatory disease of the central nervous system, caused by an autoimmune reaction. Treatment options have largely increased over the years. In this article, we present two clinical cases.
View Article and Find Full Text PDFThe Role of TNF-α in Alzheimer's Disease: A Narrative Review.
Cells
December 2023
Department of Medicine, Surgery and Neuroscience, University of Siena, Viale Bracci 2, 53100 Siena, Italy.
This review analyzes the role of TNF-α and its increase in biological fluids in mild cognitive impairment, and Alzheimer's disease (AD). The potential inhibition of TNF-α with pharmacological strategies paves the way for preventing AD and improving cognitive function in people at risk for dementia. We conducted a narrative review to characterize the evidence in relation to the involvement of TNF-α in AD and its possible therapeutic inhibition.
View Article and Find Full Text PDFα-Blocker Use in Hemodialysis: The Japan Dialysis Outcomes and Practice Patterns Study.
Kidney Med
September 2023
Department of Nephrology, Nara Medical University, Nara, Japan.
Rationale & Objective: Despite α-blockers' use for hypertension as add-on therapy in patients treated with hemodialysis, scant information is available on their association, particularly with safety, in these patients.
Study Design: Prospective cohort study.
Setting & Participants: patients treated with hemodialysis and receiving antihypertensive agents in the Japan Dialysis Outcomes and Practice Patterns Study, phases 4-6, were analyzed.
Article Synopsis
- - The report describes a rare case of a 36-year-old male who developed bacterial abscess-forming prostatitis while being treated with adalimumab for hidradenitis suppurativa, presenting with anogenital pain and dysuria.
- - Initial treatment included antibiotics after suspicion of acute prostatitis; however, further imaging revealed a complex abscess linked to the prostate, leading to the need for drainage and intensive antibiotic therapy.
- - The case underscores the importance of monitoring for adverse effects from immunomodulating drugs and suggests that physicians should remain vigilant and prompt in their diagnostic approach to similar uncommon presentations.
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