In future fusion reactors, heating system efficiency is of the utmost importance. Photo-neutralization substantially increases the neutral beam injector (NBI) efficiency with respect to the foreseen system in the International Thermonuclear Experimental Reactor (ITER) based on a gaseous target. In this paper, we propose a telescope-based configuration to be used in the NBI photo-neutralizer cavity of the demonstration power plant (DEMO) project. This configuration greatly reduces the total length of the cavity, which likely solves overcrowding issues in a fusion reactor environment. Brought to a tabletop experiment, this cavity configuration is tested: a 4 mm beam width is obtained within a ≃1.5 m length cavity. The equivalent cavity g factor is measured to be 0.038(3), thus confirming the cavity stability.
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http://dx.doi.org/10.1364/AO.57.00B122 | DOI Listing |
Eur J Cancer
January 2025
Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, UK; Institute of Cancer Research, London, UK. Electronic address:
Background: Ossifying fibromyxoid tumour is a rare mesenchymal soft tissue sarcoma with uncertain differentiation and variable metastatic potential.
Patients And Methods: This study offers a retrospective analysis of 23 patients diagnosed with OFMT between 1993 and 2024.
Results: The tumours most commonly arose in the extremities and trunk, with all patients undergoing surgical resection of the primary tumour.
Int J Pharm
January 2025
Institut Galien Paris-Saclay, CNRS UMR8612, 17 avenue des Sciences, 91400 Orsay, France. Electronic address:
Multiparticulate drug delivery systems offer advantages in controlled release, dose flexibility, and personalized medicine. Fusion prilling, a process that produces spherical lipid-based microparticles through vibrating nozzles, is gaining interest in the field. This study aims to explore the use of fusion prilling to encapsulate crystallizable water-in-oil emulsions, enabling the incorporation of hydrophilic active pharmaceutical ingredients (APIs) within lipid matrices.
View Article and Find Full Text PDFBiomater Adv
January 2025
Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Alternative meat production technologies offer the potential to alleviate many of the ethical, environmental, and public health concerns associated with conventional meat production. Cultured meat produced using cell culture technology promises to become a viable alternative to animal-raised meat for the future of the food industry. The process of cultured meat production relies on cell sources harvested from livestock such as bovine, swine, and chicken.
View Article and Find Full Text PDFBlood
January 2025
Children's Hospital of Philadelphia & University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States.
Robust genetic characterization of paediatric AML has demonstrated that fusion oncogenes are highly prevalent drivers of AML leukemogenesis in young children. Identification of fusion oncogenes associated with adverse outcomes has facilitated risk stratification of patients, although successful development of precision medicine approaches for most fusion-driven AML subtypes have been historically challenging. This knowledge gap has been in part due to difficulties in targeting structural alterations involving transcription factors and in identification of a therapeutic window for selective inhibition of the oncofusion without deleterious effects upon essential wild-type proteins.
View Article and Find Full Text PDFSpine J
January 2025
Hoag Orthopedics, 16300 Sand Canyon Ave., Suite. 500, Irvine, CA 92618, United States. Electronic address:
Background Context: Lumbar interbody fusion (LIF) is a common surgical intervention for treating lumbar degenerative disorders. Increasing demand has contributed to ever-increasing healthcare expenditure and economic burden. To address this, cost-utility analyses (CUAs) compare value in the context of patient outcomes.
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