An Unreported Cause of Intrathecal Baclofen Withdrawal Symptoms in a Woman With Spastic Cerebral Palsy Who Received Intrathecal Gablofen.

J Neurosci Nurs

Questions or comments about this article may be directed to Sylvia A. Duraski, MS ANP-BC CRRN CBIS, at She is a Nurse Practitioner, Marianjoy Medical Group, Part of Northwestern Medicine, and Adjunct Instructor, Department of Physical Medical, Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Bartlett, IL. Anjum Sayyad, MD FAAPMR, is Assistant Professor, CMS; Residency Program Director; and Medical Director, Day Rehabilitation, Marianjoy Rehabilitation Hospital, Part of Northwestern Medicine, Medical Director Stroke Rehabilitation, Central Dupage Hospital, Aurora, IL.

Published: April 2018

This article details an unreported potential cause of withdrawal symptoms in a patient with cerebral palsy who experienced intrathecal baclofen withdrawal shortly after placement of a baclofen pump with subsequent refill with Gablofen. Initial implantation of the baclofen pump with Lioresal occurred after a successful hospital trial of intrathecal injection via lumbar puncture. However, later, the patient did experience signs and symptoms of baclofen withdrawal after a pump refill was performed with Gablofen.

Download full-text PDF

Source
http://dx.doi.org/10.1097/JNN.0000000000000355DOI Listing

Publication Analysis

Top Keywords

baclofen withdrawal
12
intrathecal baclofen
8
withdrawal symptoms
8
cerebral palsy
8
baclofen pump
8
baclofen
5
unreported intrathecal
4
withdrawal
4
symptoms woman
4
woman spastic
4

Similar Publications

We present the case of a 45-year-old male with a history of multiple sclerosis complicated by spasticity and paraplegia, who developed altered mental status and type II respiratory failure requiring intubation on the same day his intrathecal baclofen pump was refilled by his pain physician. Shortly after admission, the patient experienced cardiac arrest four times within two hours until the pump contents were aspirated, and the patient was stabilized. This case report emphasizes the significance of vigilance and prompt recognition of intrathecal baclofen poisoning, which can lead to life-threatening toxicities and withdrawals.

View Article and Find Full Text PDF

Intrathecal morphine is associated with the complication of catheter tip granuloma which causes symptoms of decreased pain control, increased required dose, and neurological deficit. Catheter tip granulomas from intrathecal baclofen are thought to never occur because of the mechanism by which intrathecal morphine causes granulomas. We present a case of an intrathecal baclofen induced scarring of a catheter tip with clinical characteristics similar to some symptoms of granuloma.

View Article and Find Full Text PDF

The off-label use of an intravenous dexmedetomidine infusion is an option for refractory symptoms in pediatric palliative care with a few published cases of in-home use, most limited to end-of-life care. After an intrathecal baclofen pump malfunction with meningitis and medication withdrawal, a 17-year-old adolescent with quadriparetic cerebral palsy and paroxysmal autonomic instability experienced relief of refractory pain and dystonia with an in-home intravenous dexmedetomidine infusion. His interdisciplinary care team collaborated to establish safety measures and adjust his home medication regimen to further improve quality of life well before his end of life.

View Article and Find Full Text PDF

Objective: To report a case of intrathecal pump failure following months of diminishing benefit from intrathecal baclofen, and to heighten awareness that intrathecal pump malfunction can occur without precipitating events.

Case Report: A 40 year-old woman with multiple sclerosis and spastic paraplegia developed worsening spasticity after ten months of therapeutic stability with intrathecal baclofen. After other causes were pursued, this was discovered to be due to pump malfunction only thirteen months after implantation.

View Article and Find Full Text PDF

Background: Despite alcohol use being a risk factor for numerous health-related conditions and alcohol use disorder (AUD) recognized as a disease, there was limited research in India until 2010. This narrative review aims to evaluate AUD-related research in India from 2010 to July 2023.

Methods: A PubMed search used key terms for AUD in India after 2010.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!