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| http://dx.doi.org/10.14744/AnatolJCardiol.2018.05914 | DOI Listing |
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Background: Aggregation of the hyperphosphorylated tau protein in neurofibrillary tangles (NFTs) is a pathological hallmark of Alzheimer's Disease (AD). Several kinases contribute to the pathological phosphorylation of tau (pTau). However, kinase-targeted therapies for AD have failed in clinical trials due to largely unknown mechanism of action, low efficacy, and severe side-effects.
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Cancer, particularly skin cancer, is a major cause of mortality worldwide, with melanoma being one of the most aggressive and challenging to treat types. Current therapeutic options, such as dacarbazine (DTIC), have limitations due to dose-related toxicities like liver toxicity. Therefore, there is a need for new and effective treatments for melanoma.
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