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Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci.
World Allergy Organ J
January 2025
Institute of Life Science, Chongqing Medical University, Chongqing, China.
Background: Allergic rhinitis (AR) is a common chronic respiratory disease that can lead to the development of various other conditions. Although genetic risk loci associated with AR have been reported, the connections between these loci and AR comorbidities or other diseases remain unclear.
Methods: This study conducted a phenome-wide association study (PheWAS) using known AR risk loci to explore the impact of known AR risk variants on a broad spectrum of phenotypes.
Ocular rosacea without facial erythema involvement manifesting as bilateral multiple recurrent chalazions: A case report.
World J Clin Cases
June 2024
Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, Zhejiang Province, China.
Article Synopsis
- Ocular rosacea can be misdiagnosed due to the lack of reliable diagnostic tests and may present with symptoms like recurrent chalazion and dry eyes without facial redness.* -
- A 63-year-old woman experienced multiple chalazion that recurred even after surgical removal, and her condition was associated with significant chronic inflammation as seen in pathology studies.* -
- Treatment with oral antibiotics doxycycline and azithromycin led to resolution of symptoms, highlighting the need for ophthalmologists to consider skin diseases when diagnosing ocular issues.*
Age and number of lesions predict chalazion recurrence.
Orbit
June 2024
Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA.
Article Synopsis
- The study investigates the recurrence of chalazion (a common eye condition) in pediatric patients who undergo surgery, particularly focusing on the risks of multiple anesthetic exposures in children under three.
- A review of 649 patient records over five years revealed that less than one-third experienced a recurrence after surgery, with younger age, female sex, and the number of lesions drained being significant risk factors.
- The findings highlight the need for ophthalmologists to balance the likelihood of recurrence with the potential risks of anesthesia, especially for younger children.
Intratarsal Keratinous Cyst Clinically Misdiagnosed as a Chalazion.
Dermatopathology (Basel)
April 2024
Postgraduate Program in Dentistry, Department of Dentistry, State University of Paraíba (UEPB), Campina Grande 58429-600, PB, Brazil.
Article Synopsis
- - The intratarsal keratinous cyst (IKC) is a new type of eyelid cyst that can often be confused with a chalazion, leading to misdiagnosis.
- - A 61-year-old male had a firm nodule on his upper eyelid, initially thought to be a chalazion; an excisional biopsy revealed it was actually an IKC.
- - Accurate diagnosis is crucial, as IKCs need complete surgical removal to prevent multiple recurrences, unlike chalazions which may resolve on their own.
Neurofibroma: Case Series with Clinical Features and Recommendations.
Acta Neurol Taiwan
September 2024
Dr. Ruth K. M. Pfau Civil Hospital Karachi, Dow University of Health Sciences, Karachi, Pakistan.
Neurofibroma is an autosomal benign disorder. It can be localized, diffuse or invasive like plexiform neurofibroma that involves the nerves, muscle, tissues, skeleton. It represents itself as a destructive variant of neurofibroma, mostly present as orbital or periorbital neurofibroma or may be associated with autosomal dominant disease.
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