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Machine learning-based assessment of morphometric abnormalities distinguishes bipolar disorder and major depressive disorder.
Neuroradiology
January 2025
Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Introduction: Bipolar disorder (BD) and major depressive disorder (MDD) have overlapping clinical presentations which may make it difficult for clinicians to distinguish them potentially resulting in misdiagnosis. This study combined structural MRI and machine learning techniques to determine whether regional morphological differences could distinguish patients with BD and MDD.
Methods: A total of 123 participants, including BD (n = 31), MDD (n = 48), and healthy controls (HC, n = 44), underwent high-resolution 3D T1-weighted imaging.
Consensus molecular subtyping of colorectal carcinoma brain metastases reveals a metabolic signature associated with poor patient survival.
Mol Oncol
January 2025
Department of Medicine A, Hematology, Oncology and Pneumology, University of Münster, Germany.
The transcriptomic classification of primary colorectal cancer (CRC) into distinct consensus molecular subtypes (CMSs) is a well-described strategy for patient stratification. However, the molecular nature of CRC metastases remains poorly investigated. To this end, this study aimed to identify and compare organotropic CMS frequencies in CRC liver and brain metastases.
View Article and Find Full Text PDFInterpretable and integrative deep learning for discovering brain-behaviour associations.
Sci Rep
January 2025
University Paris-Saclay, CEA, CNRS, Neurospin, Baobab UMR 9027, Gif-sur-Yvette, 91191, France.
Recent advances highlight the limitations of classification strategies in machine learning that rely on a single data source for understanding, diagnosing and predicting psychiatric syndromes. Moreover, approaches based solely on clinician labels often fail to capture the complexity and variability of these conditions. Recent research underlines the importance of considering multiple dimensions that span across different psychiatric syndromes.
View Article and Find Full Text PDFHow gender shapes practice choices among family medicine residents and early career family physicians: a Canadian qualitative study.
BJGP Open
January 2025
Primary Care Research Unit, Department of Family Medicine, Dalhousie University, Halifax, Canada
Background: The practice choices of family medicine residents and early career family physicians shape access to primary care. A growing proportion of family physicians are women.
Aim: This study examined how gender operates in shaping family physician practice choices and subsequent practice patterns.
A Mobile Health Intervention to Support Collaborative Decision-Making in Mental Health Care: Development and Usability.
JMIR Form Res
January 2025
Early Intervention in Psychosis Advisory Unit for South-East Norway, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Background: Shared decision-making between clinicians and service users is crucial in mental health care. One significant barrier to achieving this goal is the lack of user-centered services. Integrating digital tools into mental health services holds promise for addressing some of these challenges.
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