AI Article Synopsis
- Neuroinflammation linked to macrophages increases Prostaglandin E (PGE), which is associated with neuropathic pain.
- Traditional NSAIDs reduce PGE by inhibiting cyclooxygenase but can cause side effects.
- A new nanoemulsion with celecoxib targets the site of injury, provides effective pain relief, and minimizes drug dosage compared to oral administration.
Article Abstract
Neuroinflammation involving macrophages elevates Prostaglandin E, associated with neuropathic pain. Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) inhibits cyclooxygenase, reducing PGE. However, NSAIDs cause physiological complications. We developed nanoemulsions incorporating celecoxib and near infrared dye. Intravenous injected nanoemulsion is incorporated into monocytes that accumulate at the injury; revealed in live animals by fluorescence. A single dose (celecoxib 0.24 mg/kg) provides targeted delivery in chronic constriction injury rats, resulting in significant reduction in the visualized inflammation, infiltration of macrophages, COX-2 and PGE. Animals exhibit relief from hypersensitivity persisting at least four-days. The total body burden of drug is reduced by >2000 fold over oral drug delivery.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056892 | PMC |
| http://dx.doi.org/10.1016/j.jneuroim.2018.02.010 | DOI Listing |
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