AI Article Synopsis
- Rotavirus is a major cause of severe diarrhea in young children in Asia, leading to 145,000 deaths annually, prompting this study across Myanmar, Sri Lanka, and Nepal from 2009 to 2015.
- Researchers collected stool samples from infected children and identified different rotavirus strains using advanced genetic testing (RT-PCR).
- The study found significant variation in rotavirus strains, with G12P[8], G1P[8], and G12P[6] being the most prevalent, highlighting the need for ongoing monitoring of these viruses to inform vaccination efforts.
Article Abstract
Background: In Asia, rotavirus accounts for approximately 45% of admissions due to acute gastroenteritis in children <5 years, and causes about 145,000 deaths every year. We studied the distribution of rotavirus strains from Myanmar, Sri Lanka, and Nepal during 2009-2015.
Methods: Stool samples collected from children <5 years of age hospitalized with acute diarrhea in the three sites and positive for rotavirus antigen by enzyme immunoassay (EIA) were sent to the Christian Medical College, Vellore from 2009 to 2015. G and P typing of rotavirus strains were performed using reverse-transcription polymerase chain reaction (RT-PCR).
Result: Of the 2354 EIA positive samples tested, G12P[8] (36.8%), G1P[8] (30.1%), and G12P[6] (41.3%) were the most common strains isolated from Myanmar, Sri Lanka, and Nepal respectively.
Conclusion: There was substantial diversity of rotavirus genotypes, and continued surveillance in developing countries of Asia will help in understanding the epidemiology of rotavirus before and after introduction of vaccines.
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| http://dx.doi.org/10.1016/j.vaccine.2018.02.092 | DOI Listing |
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