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| http://dx.doi.org/10.1016/j.bjhh.2017.10.001 | DOI Listing |
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CircCCT2/miR-146a-5p/IRAK1 axis promotes the development of head and neck squamous cell carcinoma.
BMC Cancer
January 2025
Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Background: Head and neck squamous cell carcinoma (HNSCC), a highly invasive malignancy with a poor prognosis, is one of the most common cancers globally. Circular RNAs (circRNAs) have become key regulators of human malignancies, but further studies are necessary to fully understand their functions and possible causes in HNSCC.
Methods: CircCCT2 expression levels in HNSCC tissues and cells were measured via qPCR.
ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage.
Nat Struct Mol Biol
January 2025
Department of Biological Chemistry, School of Medicine, University of California Irvine, Irvine, CA, USA.
DNA damage in cells induces the expression of inflammatory genes. However, the mechanism by which cells initiate an innate immune response in the presence of DNA lesions blocking transcription remains unknown. Here we find that genotoxic stresses lead to an acute activation of the transcription factor NF-κB through two distinct pathways, each triggered by different types of DNA lesions and coordinated by either ataxia-telangiectasia mutated (ATM) or IRAK1 kinases.
View Article and Find Full Text PDFA Network and Pathway Analysis of Genes Associated With Atrial Fibrillation.
Cardiovasc Ther
January 2025
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Article Synopsis
- Atrial fibrillation (AF) is influenced by both genetics and the environment, and existing genetic studies have identified numerous genes associated with AF, but their functions and interactions remain unclear.
- Researchers conducted a detailed analysis of 254 AF-associated genes, revealing significant biological pathways related to heart activity and connections to diseases like cancer and inflammation through pathway crosstalk.
- They also identified 24 novel genes potentially linked to AF, with six showing differential expression in AF patients, suggesting a common genetic basis between AF and other diseases, which could aid in discovering additional AF risk factors.
Prognostic value of ubiquitination-related differentially expressed genes in esophageal squamous cell carcinoma: a comprehensive analysis and future directions.
J Thorac Dis
November 2024
Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Background: Esophageal squamous cell carcinoma (ESCC) represents a considerable health challenge, primarily due to its poor prognosis and the limited availability of effective therapeutic interventions. Ubiquitination, a vital post-translational modification, is integral to cellular regulation; nonetheless, its role in ESCC has not been thoroughly explored. This study aims to identify ubiquitination-related differentially expressed genes (URDEGs) that possess prognostic significance in the context of ESCC.
View Article and Find Full Text PDFClonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity.
Nat Cardiovasc Res
December 2024
Division of Cellular Therapy, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Certain somatic mutations provide a fitness advantage to hematopoietic stem cells and lead to clonal expansion of mutant blood cells, known as clonal hematopoiesis (CH). Among the most common CH mutations, ASXL1 mutations pose the highest risk for cardiovascular diseases (CVDs), yet the mechanisms by which they contribute to CVDs are unclear. Here we show that hematopoietic cells harboring C-terminally truncated ASXL1 mutant (ASXL1-MT) accelerate the development of atherosclerosis in Ldlr mice.
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