Synthesis, Molecular Docking, and Antimycotic Evaluation of Some 3-Acyl Imidazo[1,2-a]pyrimidines.

A series of 3-benzoyl imidazo[1,2-]pyrimidines, obtained from -heteroarylformamidines in good yields, was tested in silico and in vitro for binding and inhibition of seven species ( (ATCC 10231), (CD36), (CBS138), (ATCC 6260), , (ATCC 6358) and (MYA-3404)). To predict binding mode and energy, each compound was docked in the active site of the lanosterol 14α-demethylase enzyme (CYP51), essential for fungal growth of species. Antimycotic activity was evaluated as the 50% minimum inhibitory concentration (MIC50) for the test compounds and two reference drugs, ketoconazole and fluconazole. All test compounds had a better binding energy (range: -6.11 to -9.43 kcal/mol) than that found for the reference drugs (range: 48.93 to -6.16 kcal/mol). In general, the test compounds showed greater inhibitory activity of yeast growth than the reference drugs. Compounds and were the most active, indicating an important role in biological activity for the benzene ring with electron-withdrawing substituents. These compounds show the best MIC50 against C. respectively. The current findings suggest that the 3-benzoyl imidazo[1,2-]pyrimidine derivatives, herein synthesized by an accessible methodology, are potential antifungal drugs.