The morphology of nanomedicines has a large influence on the anticancer efficiency of therapeutic agents in biological systems. In this study, camptothecin (CPT)-based nanodrugs with helical and spherical shapes were simply built without the need of any additional carriers. Self-deliverable spherical nanodrug represented a therapeutic advantage over the helical one, which was uncovered from the in vitro toxicity assay. Confocal imaging study indicated that the better outcome of spherical nanodrug was ascribed to the faster cellular uptake. With the aid of sonication treatment, helical nanodrugs with different lengths (HD-1, HD-2, HD-3, HD-4) were created. In comparing with the longest HD-1, the drug release kinetics indicated that the shortest HD-4 exhibited a 20% elevation in cumulative drug release at the first 10 h. The internalized drug amount of HD-4 was three-fold higher than that of HD-1 after the cultivation with 4T1 cells for 2 h. These results demonstrated that the anticancer efficacy of helical nanodrugs was inversely proportional to their lengths. The strategy demonstrated here presents great promise for the preparation of nanodrugs with suitable morphology for cancer therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.colsurfb.2018.02.054 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Therapeutic approach of carbon nanotube: Revolutionize nanomaterial in biomedical and pharmaceutical sector.
J Food Drug Anal
December 2024
Pranveer Singh Institute of Technology, Pharmacy, Kanpur, India.
Carbon nanotubes (CNTs) has emerged as a promising nanomaterial with a wide range of potential applications due to their unique structural, mechanical, electrical, and thermal properties. However, numerous obstacles must be overcome for CNTs to be used successfully, including low solubility, aggregation, and a lack of specialized functions. Diverse techniques have been developed for the manufacture, purification, and functionalization of CNTs in order to overcome these issues.
View Article and Find Full Text PDFOrganotin(IV) derivatives of 4-chloro-2-methylphenoxyacetic acid: synthesis, spectral characterization, X-ray structures, anticancer, enzyme inhibition, antileishmanial, antimicrobial and antioxidant activities.
J Biomol Struct Dyn
January 2025
Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan.
Four organotin(IV) carboxylate complexes; (CH)SnL (), CHSnL (), (CH)SnL () and (CH)SnL () are synthesized by the condensation reaction of organotin(IV) chlorides with sodium-4-chloro-2-methylphenoxyacetate (). The FT-IR spectra suggested bridging/chelating bidentate coordination of the ligand to the tin atom. Single-crystal XRD analysis authenticated the FT-IR findings for and .
View Article and Find Full Text PDFThe hybrid lipoplex induces cytoskeletal rearrangement via autophagy/RhoA signaling pathway for enhanced anticancer gene therapy.
Nat Commun
January 2025
Nanomedicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, P. R. China.
Delivering plasmid DNA (pDNA) to solid tumors remains a significant challenge due to the requirement for multiple transport steps and the need to promote delivery efficiency. Herein, we present a virus-mimicking hybrid lipoplex, composed of an arginine-rich cationic lipid, hyaluronic acid derivatives coated gold nanoparticles, and pDNA. This system induces cytoskeletal rearrangements through "outside-in" mechanical and "inside-out" biochemical signaling, overcoming intra- and intercellular barriers to enhance pDNA delivery.
View Article and Find Full Text PDFTargeting the tumor microenvironment with mesenchymal stem cells based delivery approach for efficient delivery of anticancer agents: An updated review.
Biochem Pharmacol
December 2024
Department of Ophthalmology, the Second Hospital of Jilin University, Changchun 130000, China. Electronic address:
Drug delivery to cancer cells continues to present a major therapeutic challenge. Mesenchymal stem cells (MSCs) possess an intrinsic ability to migrate specifically to tumor tissues, making them promising candidates for targeted drug delivery. Evidence from preclinical studies indicates that MSCs loaded with therapeutic anti-cancer agents exhibit considerable anti-tumor activity.
View Article and Find Full Text PDFZein-based nanoparticulate systems: a journey through fabrication, targeting strategies and biomedical applications.
J Biomater Sci Polym Ed
January 2025
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, Gandhinagar, India.
Zein, a plant-based protein obtained from the endosperm of corn ( L.) received colossal attention in recent years due to its promising features like being economical, mucoadhesive, gastro-resistant, biocompatible and aids to load hydrophilic and hydrophobic therapeutic agents. It can be employed for the fabrication of various drug delivery systems such as nanoparticles, micelles, hydrogels, nanofibers and films.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!