AI Article Synopsis
- The study aimed to explore 60 single nucleotide polymorphisms (SNPs) related to drug metabolism and pharmacodynamics in Burmese refugees in Fort Wayne, Indiana, to improve patient care.
- Sixty-two Burmese refugees were genotyped, and their SNP frequencies were compared with data from surrounding populations in Myanmar and the U.S.
- Findings revealed approximately 20% differences in the frequency of specific genes related to drug metabolism in the Burmese refugee population compared to other populations, indicating potential impacts on drug efficacy for these patients.
Article Abstract
Aim: The aim of this study was to investigate 60 SNPs pertaining to drug metabolism and pharmacodynamics in the Burmese refugee population in the Fort Wayne, Indiana area to better inform patient care.
Materials & Methods: Sixty-two self-identified Burmese refugees were genotyped for 60 common SNPs pertaining to pharmacokinetic and pharmacodynamic pharmacogenes. The resulting allelic frequencies were compared with Ensembl's database for surrounding populations to Myanmar and America.
Results: The frequency of OPRM1, CYP2D6, SLCO1B1, MTHFR and VKORC1 were approximately 20% different in the Burmese refugee population as compared with the Ensembl populations.
Conclusion: Our study demonstrates that genetic differences are expected to affect drug efficacy in patients with a Burmese background.
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| http://dx.doi.org/10.2217/pgs-2017-0204 | DOI Listing |
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