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Per- and polyfluoroalkyl substance (PFAS) exposure assessment in a community exposed to contaminated drinking water, New Hampshire, 2015. | LitMetric

Per- and polyfluoroalkyl substance (PFAS) exposure assessment in a community exposed to contaminated drinking water, New Hampshire, 2015.

Int J Hyg Environ Health

Region 1 New England Pediatric Environmental Health Specialty Unit, Boston, MA, United States; Pediatric Environmental Health Center, Division of General Pediatrics, Department of Medicine, Boston Children's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.

Published: April 2018

AI Article Synopsis

  • PFAS are synthetic chemicals that persist in the environment, can contaminate drinking water, and have been linked to health issues; a notable case involved contamination in New Hampshire linked to a former Air Force base.* -
  • A serum testing program was established to measure PFAS exposure in the affected community, with samples collected from 1,578 participants showing more than 94% had detectable levels of PFOS, PFOA, and PFHxS.* -
  • Analysis revealed that serum levels of these chemicals were significantly higher than the general U.S. population, indicating a need for a national response to address PFAS contamination and its health effects.*

Article Abstract

Background: Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals used in manufacturing that resist environmental degradation, can leach into drinking water, and bioaccumulate in tissues. Some studies have shown associations with negative health outcomes. In May 2014, a New Hampshire public drinking water supply was found to be contaminated with PFAS from a former U.S. Air Force base.

Objectives: We established a serum testing program to assess PFAS exposure in the affected community.

Methods: Serum samples and demographic and exposure information were collected from consenting eligible participants. Samples were tested for PFAS at three analytical laboratories. Geometric means and 95% confidence intervals were calculated and analyzed by age and exposure variables.

Results: A total of 1578 individuals provided samples for PFAS testing; >94% were found to have perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) detectable in serum. Geometric mean serum concentrations of PFOS, PFOA, and PFHxS were 8.6 μg/L (95% CI:8.3-8.9), 3.1 μg/L (95% CI: 3.0-3.2), and 4.1 μg/L (95% CI: 3.9-4.3), respectively, which were statistically higher than the general U.S.

Population: Significant associations were observed between PFAS serum concentrations and age, time spent in the affected community, childcare attendance, and water consumption.

Conclusions: PFOS, PFOA, and PFHxS were found in significantly higher levels in the affected population, consistent with PFAS drinking water contamination. Given increased recognition of PFAS contamination in the U.S, a coordinated national response is needed to improve access to biomonitoring and understand health impacts.

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Source
http://dx.doi.org/10.1016/j.ijheh.2018.02.007DOI Listing

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