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Cashmere growth control in Liaoning cashmere goat by ovarian carcinoma immunoreactive antigen-like protein 2 and decorin genes. | LitMetric

Cashmere growth control in Liaoning cashmere goat by ovarian carcinoma immunoreactive antigen-like protein 2 and decorin genes.

Asian-Australas J Anim Sci

Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Department of Life Sciences, Liaoning Normal University, Dalian, Liaoning 116029, China.

Published: May 2018

Objective: The study investigated the biological functions and mechanisms for controlling cashmere growth of Liaoning cashmere goat by ovarian carcinoma immunoreactive antigen-like protein 2 () and decorin () genes.

Methods: cDNA library of Liaoning cashmere goat was constructed in early stages. and genes related to cashmere growth were identified by homology analysis comparison. The expression location of and genes in primary and secondary hair follicles (SF) was performed using hybridization. The expression of and genes in primary and SF was performed using real-time polymerase chain reaction (PCR).

Results: hybridization revealed that and were expressed in the inner root sheath of Liaoning cashmere goat hair follicles. Real-time quantitative PCR showed that these genes were highly expressed in SF during anagen, while these genes were highly expressed in primary hair follicle in catagen phase. Melatonin (MT) inhibited the expression of OCIAD2 and promoted the expression of DCN. Insulin-like growth factors-1 (IGF-1) inhibited the expression of OCIAD2 and DCN, while fibroblast growth factors 5 (FGF5) promoted the expression of these genes. MT and IGF-1 promoted OCIAD2 synergistically, while MT and FGF5 inhibited the genes simultaneously. MT+IGF-1/MT+FGF5 inhibited gene. RNAi technology showed that OCIAD2 expression was promoted, while that of DCN was inhibited.

Conclusion: Activation of bone morphogenetic protein (BMP) signaling pathway up-regulated OCIAD2 expression and stimulated SF to control cell proliferation. gene affected hair follicle morphogenesis and periodic changes by promoting transforming growth factor-β (TGF-β) and BMP signaling pathways. and genes have opposite effects on TGF-β signaling pathway and inhibit each other to affect the hair growth.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930275PMC
http://dx.doi.org/10.5713/ajas.17.0517DOI Listing

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