A comparative study of the toxicity and hemocompatibility of chitosan and its derivatives with different acetylation degrees, molecular masses, charges, and hydrophobicity has been performed. It has been shown that only positively charged chitosan derivatives activate platelets and suppress cell proliferation, regardless of the acetylation degree, molecular mass, and hydrophobicity. Chitosan quaternization decreases toxicity at a low degree of substitution and abruptly increases it at a high one. Negatively charged chitosan derivatives were nontoxic and compatible with blood components. It was concluded that the toxicity of chitosan and its derivatives is defined by their charge and solubility at a neutral pH.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Naturally derived hydrogels for wound healing.
Ther Deliv
January 2025
Faculty of Fundamental Sciences, Van Lang University, Ho Chi Minh City, Vietnam.
Natural hydrogels have garnered increasing attention due to their natural origins and beneficial roles in wound healing. Hydrogel water-retaining capacity and excellent biocompatibility create an ideal moist environment for wound healing, thereby enhancing cell proliferation and tissue regeneration. For this reason, naturally derived hydrogels formulated from biomaterials such as chitosan, alginate, gelatin, and fibroin are highly promising due to their biodegradability and low immunogenic responses.
View Article and Find Full Text PDFAcid-decorated chitosan-magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑ones.
Sci Rep
January 2025
Department of Chemistry, Faculty of Science, Arak University, Arak, 38481-77584, Iran.
In this study, a novel hybrid nanostructure consisting of acid-decorated chitosan and magnetic AlFeO nanoparticles was fabricated. The acid-decorated chitosan provided a stable and biocompatible matrix for the magnetic AlFeO nanoparticles. Various techniques including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction patterns (XRD), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), specific surface area (BET), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS) were used to characterize and confirm the successful synthesis of the hybrid nanostructure.
View Article and Find Full Text PDFVersatile applications of cobalt and copper complexes of biopolymeric Schiff base ligands derived from chitosan.
Int J Biol Macromol
January 2025
Catalytic Applications Laboratory, Department of Chemistry, School of Basic Sciences, Faculty of Science, Manipal University Jaipur, Dehmi Kalan, Jaipur 303007, Rajasthan, India. Electronic address:
In the present study, biopolymeric Schiff base (SB) ligands were synthesized from chitosan and isatin. Consequently, their earth abundant transition metal complexes of cobalt and copper were synthesized. All compounds were extensively characterized using FTIR and UV spectroscopy, thermo-gravimetric (TG) analysis, X-ray powder diffraction (XRD) and FESEM (field emission scanning electron microscopy).
View Article and Find Full Text PDFKeratin/chitosan film promotes wound healing in rats with combined radiation-wound injury.
J Mater Sci Mater Med
January 2025
Department of Nuclear Medicine, Chongqing University Cancer Hospital, No. 181 HanYu St, Shapingba District, Chongqing, 400030, PR China.
Human hair keratin, a natural protein derived from human hair, has emerged prominently in the field of wound repair, showcasing its unique regenerative capabilities and extensive application potential. However, it is a challenge for the keratin to efficiently therapy the impaired wound healing, such as combined radiation-wound injury. Here, we report a keratin/chitosan (KRT/CS) film for skin repair of chronic wounds in in rats with combined radiation-wound injury.
View Article and Find Full Text PDFInterfacial Adsorption Interactions of Dyes and Chitosan/Activated Carbon@Curcumin Derivatives in Single-Component and Binary Solutions.
Langmuir
January 2025
Hephaestus Laboratory, School of Chemistry, Faculty of Sciences, Democritus University of Thrace, GR-65404 Kavala, Greece.
The remediation of wastewaters contaminated with dyes (discharged mainly from industry) is very important for preserving environmental quality and human health. In this study, a new composite chitosan (CS)-based adsorbent combined with activated carbon (AC) and curcumin (Cur) (abbreviated hereafter as CS/AC@Cur) in three different ratios (12.5%, 25%, and 50%) was synthesized for the removal of anionic [reactive black 5 (RB5)] and cationic [methylene blue (MB)] dyes in single-component or binary systems.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!