We report two cases of transient significantly elevated plasma cobalamin (B12) in geriatric patients acutely admitted with fever, increased C-reactive protein and X-ray verified pneumonia. Extensive diagnostic workup did not reveal kidney or liver disease, neither any signs of cancer. Furthermore, none of the patients had received therapeutic B12 supplementation prior to admission. In both cases, plasma B12 normalized at an out-patient control few months later. We were not able to identify the reason for the initial B12 elevation in any of the patients, since none of the usually recognized causes were evident. Since both patients had an infection and temporarily elevated B12, we suggest a possible inflammatory response or a vitamin B12 production by the infectious agents as the cause. Both suggestions, however, need further exploration.
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http://dx.doi.org/10.1080/00365513.2018.1447143 | DOI Listing |
J Food Sci
December 2024
Nutrition, Biochemistry and Toxicology Division, Defence Food Research Laboratory (DRDO-DFRL), Mysore, India.
The present study aimed to fabricate a co-deliver system using zein/gum arabic (GA) polymers for enhanced stability and bioavailability of vitamins (B6 and B12). The anti-solvent evaporation method was used for the preparation of PC-ZG NPs (pyridoxine-cyanocobalamin zein-GA nanoparticles). The process conditions were statistically optimized using the design of Box-Behnken.
View Article and Find Full Text PDFEpigenomics
January 2025
Mother and Child Health, ICMR - Collaborating Centre of Excellence (CCoE), Interactive Research School for Health Affairs, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.
Aim: This study aims to examine the gene expression and DNA methylation patterns of angiogenic factors in the placentae of Indian women who underwent assisted reproductive technology (ART) procedures and their association with maternal one-carbon metabolites and birth outcome.
Methods: Placental gene expression and DNA methylation of angiogenic factors (, , , ) in Indian women who underwent ART procedures ( = 64) and women who conceived naturally (Non-ART) ( = 93) was investigated using RT-qPCR and Epitect Methyl-II PCR assay kits. Maternal plasma one-carbon metabolites were assessed by CMIA technology.
Biochimie
November 2024
Unitat de Medicina Preventiva, ANUT-DSM, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, (FMCS URV), Spain; IISPV, Areas of Family and Community Medicine, Spain; CIBERobn ISCIII, Spain. Electronic address:
Pan Afr Med J
November 2024
Clinical Investigation Center, Habib Bourguiba University Hospital of Sfax, Sfax, Tunisia.
Introduction: the relationship between elevated plasma homocysteine (Hcy) and stroke has been established, but this association remains indistinct in cryptogenic stroke in adults. Our aim is to investigate the association between homocysteine, vitamins B9 and B12, and cryptogenic stroke. Furthermore, to determine the correlation between methylenetetrahydrofolate reductase (MTHFR) polymorphism and biochemical levels in plasma.
View Article and Find Full Text PDFSci Rep
October 2024
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto, Japan.
The folate requirements for beef cattle have not been established. Therefore, we investigated whether rumen-unprotected folic acid supplementation during the fattening period affects carcass traits and nutritional metabolism in Japanese Black beef cattle. Eighteen Beef cattle aged 16 months were divided into three groups: control, low folic acid supplementation (0.
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