Germ cell tumours are rare intracranial tumours. The basal ganglionic location of these tumours comprise a rare group. Bilateral involvement of the basal ganglia by germ cell tumours is distinctly rare and have only been reported in Japanese patients. We present the first report of bilateral basal ganglionic germ cell tumour in a non-Japanese patient.
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Ann Oncol
March 2025
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Background: Post-chemotherapy retroperitoneal lymph node dissection (pcRPLND) is integral to multimodal treatment of patients with metastatic non-seminomatous germ cell tumors (NSGCT). We review pathologic and long-term outcomes of pcRPLND following first-line chemotherapy with a focus on residual mass size and primary tumor histology. Our goal was to identify new predictive approaches that can refine surgical indications.
View Article and Find Full Text PDFInt Immunopharmacol
March 2025
Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Department of Developmental & Regenerative Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China. Electronic address:
Background: Ischemia-reperfusion (I/R) injury is the main pathophysiology of testicular torsion-detorsion (T/D). However, there is no safe and effective treatment for testicular I/R injury.
Methods: The levels of NAD related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).
Syst Biol Reprod Med
December 2025
Laboratory of Histology and Embryology, Aristotle University Medical School, Thessaloniki, Greece.
One of the major advancements in fertilization (IVF) has been the development of culture media that enhance gamete maturation and sustain embryo development up to the blastocyst stage. The deep understanding of the mechanisms involved in gametogenesis and the complex sequence of events surrounding nuclear and cytoplasmic maturation has also enabled the development of efficient maturation (IVM) protocols. This review outlines the major landmarks in the history of maturation of oocytes, the advantages and importance of its clinical application in human, especially in patients with Polycystic Ovary Syndrome (PCOS), Resistant Ovary Syndrome, high antral follicle count or oncology patients, as well as the safety and efficacy of the technique.
View Article and Find Full Text PDFJ Chem Ecol
March 2025
International Centre of Insect Physiology and Ecology, P. O. Box 30772-00100, Nairobi, Kenya.
The fall armyworm (FAW), Spodoptera frugiperda, is a serious invasive crop pest and threat to food security. Conventional pest control approaches using chemical pesticides can lead to adverse environmental and human health problems calling for safer alternative pest management options. Volatile organic compounds (VOCs) released by plants constitutively and in response to herbivory have been shown to enhance ecologically benign biocontrol alternatives to chemical insecticides for pest management.
View Article and Find Full Text PDFMol Biol Cell
March 2025
Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607.
Specialized, maternally derived ribonucleoprotein (RNP) granules play an important role in specifying the primordial germ cells in many animal species. Typically, these germ granules are small (∼100 nm to a few microns in diameter) and numerous; in contrast, a single, extremely large granule called the oosome plays the role of germline determinant in the wasp The organizational basis underlying the form and function of this unusually large membraneless RNP granule remains an open question. Here we use a combination of super-resolution and transmission electron microscopy to investigate the composition and morphology of the oosome.
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