AI Article Synopsis
- Malaria is a major infectious disease causing high mortality in tropical regions, worsened by the increasing resistance of parasites to antimalarial drugs and mosquitoes to insecticides.
- There is a push for developing new, targeted, and effective antimalarial agents, with endophytic fungi emerging as promising sources of unique bioactive compounds.
- The review examines literature from 1996 to 2017, detailing 135 fungal metabolites with reported antimalarial activities, highlighting their structures, sources, and potential for drug development.
Article Abstract
Malaria is one of the major infectious diseases and foremost cause of mortality and morbidity in many subtropical and tropical regions. In the last years, the situation has become worst in many ways, due to increase in the parasites resistance to various available antimalarial agents. Furthermore, malaria`s control is beginning to be more sophisticated by the parallel spread of mosquito vector`s resistance to the available insecticides. Recently, there is a wide consensus to seek for target specific, safe, affordable, and effective new antimalarial agents, which can compete with synthetic ones. Endophytic fungi are of a growing interest as prominent sources of structurally unique bioactive natural products. The bio-metabolites isolated from endophytic fungi, possessing antimalarial potential may compose the base for the synthesis of novel drugs that might be utilized to withstand malaria and its resistance. For getting information on the various studies, PubMed, Google Scholar, ScienceDirect, SpringerLink, Scopus, and Wiley search was done using keywords (malaria, endophytic fungi, and antimalarial activity). The present review covers the literature published from 1996 to 2017 and highlights the metabolites for which antimalarial activities have been reported. Overall, 135 fungal metabolites and 72 references are cited. In addition, their structure, chemical class, fungal source, host, and activity have been presented. This review shows the significance of endophytic fungi as a wealthy pool of antimalarial agents.
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| http://dx.doi.org/10.2174/1389557518666180305163151 | DOI Listing |
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