AI Article Synopsis
- The ongoing goal in science is to design artificial cells that replicate the functions of natural cells through developing advanced chemical systems.
- Researchers have focused on electrochemical methods to release ions from electrodes to initiate specific catalytic reactions involving DNAzymes, which are crucial for mimicking cell behavior.
- By controlling the release of metal ions like Pb or Ag in a nucleic acid mixture, the process enhances the selection of specific DNAzymes, leading to coordinated reactions and the activation of complex chemical cascades.
Article Abstract
The design of artificial cells, which mimic the functions of native cells, is an ongoing scientific goal. The development of stimuli-responsive chemical systems that stimulate cascaded catalytic transformations, trigger chemical networks, and control vectorial branched transformations and dose-controlled processes, are the minimum requirements for mimicking cell functions. We have studied the electrochemical programmed release of ions from electrodes, which trigger selective DNAzyme-driven chemical reactions, cascaded reactions that self-assemble catalytic DNAzyme polymers, and the ON-OFF switching and dose-controlled operation of catalytic reactions. The addressable and potential-controlled release of Pb or Ag ions into an electrolyte that includes a mixture of nucleic acids, results in the metal ion-guided selection of nucleic acids yielding the formation of specific DNAzymes, which stimulate orthogonal reactions or activate DNAzyme cascades.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812549 | PMC |
| http://dx.doi.org/10.1039/c5sc00744e | DOI Listing |
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