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Synthesis of photo-responsive κ-carrageenan-based hydrogels for drug delivery application.
Int J Biol Macromol
December 2024
Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Natural polymer-based hydrogels may act as versatile platforms in controlled drug delivery. In this regard, photoactive κ-carrageenan (κ-Crg) hydrogels modified with cinnamate (CN) groups are developed for pH-sensitive release of drugs. κ-Crg-CN derivatives containing 17 %, 33 %, and 49 % cinnamate contents, named κ-Crg-CN1, κ-Crg-CN2, and κ-Crg-CN3, respectively, are prepared and cross-linked by UV-induced [2π + 2π] cycloaddition.
View Article and Find Full Text PDFInvestigations on the Impacts of Drugs or Excipients with Different Physicochemical and Compaction Properties on the Disintegration Behavior of Kollidon®SR-Based Binary Controlled Release Matrix Tablets.
AAPS PharmSciTech
October 2024
Jerash University-Faculty of Pharmacy, Department of Pharmaceutical Sciences, Jerash, Jordan.
The objective of this study was to examine the impact of the physicochemical properties of the loaded drug or excipient, the concentration of Kollidon®SR (KSR), and the mechanical characteristics of KSR compacts on their disintegration times. Using disintegration apparatus, a two-hour constraint was chosen as the process's end point. Lactose-KSR compacts subjected to the highest compression pressure and Microcrystalline cellulose-KSR compacts with KSR concentrations exceeding 30% exhibited disintegration times of less than ten minutes.
View Article and Find Full Text PDFExhaustive Search of Dietary Intake Biomarkers as Objective Tools for Personalized Nutrimetabolomics and Precision Nutrition Implementation.
Nutr Rev
September 2024
Nutrition Precision and Cardiometabolic Health Program of IMDEA-Food Institute (Madrid Institute for Advances Studies), 28040, Madrid, Spain.
Objective: To conduct an exhaustive scoping search of existing literature, incorporating diverse bibliographic sources to elucidate the relationships between metabolite biomarkers in human fluids and dietary intake.
Background: The search for biomarkers linked to specific dietary food intake holds immense significance for precision health and nutrition research. Using objective methods to track food consumption through metabolites offers a more accurate way to provide dietary advice and prescriptions on healthy dietary patterns by healthcare professionals.
Characterization of a Soft Ionization by Chemical Reaction in Transfer Ion Source Hyphenated With Supercritical Fluid Chromatography-Tandem Mass Spectrometry.
J Sep Sci
September 2024
Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas, USA.
A commercially available dielectric barrier discharge ionization (DBDI) source was tested with supercritical fluid chromatography-mass spectrometry (SFC-MS). The compound mixture investigated comprised caffeine, theobromine, theophylline, uracil, testosterone, and pyrene, diluted in methanol. Dynamic response ranges were evaluated with multiple injections at different concentrations.
View Article and Find Full Text PDFCarbon nanomaterials as electrochemical sensors for theophylline: a review.
RSC Adv
September 2024
Nanotechnology Engineering, Faculty of Advanced Technology and Multidiscipline, Universitas Airlangga Surabaya 60115 Indonesia
Article Synopsis
- Theophylline (TP) is a special medicine that helps people breathe better but needs careful monitoring to avoid harmful effects.
- Researchers are using advanced electrochemical methods to accurately measure TP levels, which is really important for safe treatment.
- This review focuses on new carbon-based sensors that improve the way we detect TP, making it more accurate and sensitive.
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