AI Article Synopsis
- - This study focuses on sepsis, a severe condition caused by an unchecked response to infection that leads to organ dysfunction and oxidative stress.
- - Researchers developed a new fluorescence chemosensor, particularly a compound called 6-methoxynaphthalene-2,3-dicarbaldehyde (MNDA), which can detect the biothiol glutathione (GSH) in live cells using advanced microscopy techniques.
- - The study also found that two other compounds can effectively detect GSH and are clinically relevant for diagnosing sepsis and predicting patient mortality, highlighting potential advances in medical diagnostic methods.
Article Abstract
Among the biothiols-related diseases, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection and can result in severe oxidative stress and damage to multiple organs. In this study, we aimed to develop a fluorescence chemosensor that can both detect GSH and further predict sepsis. In this study, two new naphthalene dialdehyde compounds containing different functional groups were synthesized, and the sensing abilities of these compounds towards biothiols and its applications for prediction of sepsis were investigated. Our study revealed that the newly developed probe 6-methoxynaphthalene-2, 3-dicarbaldehyde (MNDA) has two-photon is capable of detecting GSH in live cells with two-photon microscopy (TPM) under the excitation at a wavelength of 900 nm. Furthermore, two GSH detection probes naphthalene-2,3-dicarboxaldehyde (NDA) and 6-fluoronaphthalene-2,3-dicarbaldehyde (FNDA) not only can detect GSH in living cells, but also showed clinical significance for the diagnosis and prediction of mortality in patients with sepsis. These results open up a promising direction for further medical diagnostic techniques.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835946 | PMC |
| http://dx.doi.org/10.7150/thno.22252 | DOI Listing |
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