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Alzheimer's Disease Neuroimaging Initiative: Two decades of pioneering Alzheimer's disease research and future directions.
Alzheimers Dement
January 2025
Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, California, USA.
Editorial: Emerging trends in large-scale data analysis for neuroscience research.
Front Neuroinform
December 2024
Department of Computer Science, Brunel University London, London, United Kingdom.
Extended homogeneous field correction method based on oblique projection in OPM-MEG.
Neuroimage
January 2025
Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology, Ministry of Education, School of Instrumentation and Optoelectronic Engineering, Beihang University, 100191, Beijing, China; Hangzhou Institute of Extremely-Weak Magnetic Field Major National Science and Technology Infrastructure, Hangzhou, 310051, China; State Key Laboratory of Traditional Chinese Medicine Syndrome/Health Construction Center, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China; Hefei National Laboratory, Hefei, 230088, China. Electronic address:
Optically pumped magnetometer-based magnetoencephalography (OPM-MEG) is an novel non-invasive functional imaging technique that features more flexible sensor configurations and wearability; however, this also increases the requirement for environmental noise suppression. Subspace projection algorithms are widely used in MEG to suppress noise. However, in OPM-MEG systems with a limited number of channels, subspace projection methods that rely on spatial oversampling exhibit reduced performance.
View Article and Find Full Text PDFSchizophrenia Following Early Adolescence Prodrome: A Neurodevelopmental Subtype With Autism-like Sensorimotor and Social Cognition Deficits.
Schizophr Bull
January 2025
Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Team "Pathophysiology of psychiatric disorders", Institut de psychiatrie, CNRS GDR 3557, 75014 Paris, France.
Background And Hypothesis: While age at onset in schizophrenia (SCZ) is usually defined by age at onset of psychosis, the illness actually occurs earlier, with a prodrome often starting in childhood or adolescence. We postulated that SCZ with early-adolescence prodromes (SCZ-eaP) presents with social cognition deficits and sensorimotor impairments more similar to autism spectrum disorders (ASD) than SCZ with late-adolescence prodromes (SCZ-laP).
Study Design: The movie for the assessment of social cognition and neurological soft signs (NSS) were compared between four groups, ASD, SCZ-eaP (<15 years), SCZ-laP (>15 years), and controls (N = 119), while accounting for age, sex, intelligence quotient, education level, and medication effect.
C19orf12 gene variants causing mitochondrial membrane protein-associated neurodegeneration (MPAN).
Eur J Hum Genet
January 2025
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India.
Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a rare neurodegenerative disorder characterized by spastic paraplegia, parkinsonism and psychiatric and/or behavioral symptoms caused by variants in gene encoding chromosome-19 open reading frame-12 (C19orf12). We present here seven patients from six unrelated families with detailed clinical, radiological, and genetic investigations. Childhood-onset patients predominantly had a spastic ataxic phenotype with optic atrophy, while adult-onset patients were presented with cognitive, behavioral, and parkinsonian symptoms.
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