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Cancer Is Not (Only) a Senescence Problem. | LitMetric

Cancer Is Not (Only) a Senescence Problem.

Trends Cancer

Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC 3216, Australia; School of Biological Sciences, University of Tasmania, Private Bag 55, Hobart, TAS 7001, Australia.

Published: March 2018

AI Article Synopsis

Article Abstract

Age is one of the strongest predictors of cancer and risk of death from cancer. Cancer is therefore generally viewed as a senescence-related malady. However, cancer also exists at subclinical levels in humans and other animals, but its earlier effects on the body are poorly known by comparison. We argue here that cancer is a significant but ignored burden on the body and is likely to be a strong selective force from early during the lifetime of an organism. It is time to adopt this novel view of malignant pathologies to improve our understanding of the ways in which oncogenic phenomena influence the ecology and evolution of animals long before their negative impacts become evident and fatal.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trecan.2018.01.002DOI Listing

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