Intralymphatic spread is common in solid cancers, but has been rarely studied in lymphomas. Review of 635 extranodal specimens from 475 diffuse large B-cell lymphoma (DLBCL) patients revealed intralymphatic spread in 10 surgical resection specimens from 10 patients including 9 de novo DLBCLs and 1 Richter transformation. The prevalence in de novo DLBCL with extranodal involvements was 1.65%. The most common involved site of intralymphatic spread was the gastrointestinal tract, followed by the female genital tract and breasts. Lymphatic vessels, lined by D2-40-positive endothelial cells, were expanded by lymphoma cells, reminiscent of intravascular lymphoma or tumor emboli. None of the involved lymphatic vessels were located in the mucosa. Patients with intralymphatic spread had a trend of lower overall response rate and a trend of higher progressive disease than those without intralymphatic spread. Compared with patients without intralymphatic spread, those patients with intralymphatic spread had a shorter median overall survival (14.3 vs. 96.2 mo; P=0.004) and a shorter median progression-free survival (11.2 vs. 64.2 mo; P=0.01), respectively. Multivariate analyses showed that intralymphatic spread was an independent poor prognostic factor for overall survival (hazard ratio, 3.029; 95% confidence interval, 1.315-6.978; P=0.009), irrespective of the National Comprehensive Cancer Network-International Prognostic Index, B symptoms, and serum albumin levels. Among patients who underwent surgical resection, intralymphatic spread was still an independent prognostic factor. In conclusion, our study demonstrated extranodal intralymphatic spread in DLBCL. Inspiringly, this rare morphologic finding may serve as a new negative prognostic indicator in DLBCL with extranodal involvements.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/PAS.0000000000001045 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
White Globe Appearance-Like Findings Indicating Intralymphatic Cancer Involvement Beneath the Epithelium in Gastric Cancer.
Case Rep Gastrointest Med
October 2024
Department of Gastroenterology, Sendai City Medical Center, Miyagi, Japan.
Article Synopsis
- A 75-year-old woman was diagnosed with early-stage gastric cancer during an endoscopic examination, specifically a type 0-I carcinoma located on the middle part of her stomach.
- During the procedure, small whitish structures called white globe appearances (WGAs) were observed near the cancer area, indicating potential subepithelial cancer spread despite the surface appearing flat and noncancerous.
- Histopathology results confirmed the presence of cancer with significant lymphatic invasion, showing that the cancer had spread along the lymphatic vessels into surrounding tissues, which was likely responsible for the WGA characteristics seen during the endoscopy.
Lymphangitic Melanomatosis: Case Report of Intralymphatic Spread of Melanoma in a 66-year-old Man.
Am J Dermatopathol
May 2024
Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Melanoma with lymphatic invasion has been associated with increased risk of metastasis, but the mechanisms and clinical implications are poorly understood. Although current reports have documented angiotropic spread of melanoma and suggest lymphatic spread of melanoma to increase the likelihood of metastasis, to our knowledge, lymphangitic metastatic melanoma resembling cutaneous carcinomatosis or presenting with facial hyperpigmentation has not been described. In this case report, we describe extensive cutaneous intralymphatic spread of melanoma, or lymphangitic melanomatosis, producing macular skin pigmentation in a 66-year-old man.
View Article and Find Full Text PDFAssociation of tumor molecular factors with in-transit metastasis in primary cutaneous melanoma.
Int J Dermatol
September 2022
Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
Background: In-transit metastases (ITM) are a form of locoregional relapse representing intralymphatic metastatic spread and occur in approximately 4-9% of patients with melanoma >1 mm Breslow thickness. Our objective was to evaluate a combination of clinicopathologic risk factors and gene expression biomarkers predictive of ITM risk.
Methods: We used PCR to quantify gene expression in diagnostic biopsy tissue across a prospectively designed archival cohort of 854 consecutive thin and intermediate thickness primary cutaneous melanomas.
Tumor-associated neutrophils (TANs) in human carcinoma-draining lymph nodes: a novel TAN compartment.
Clin Transl Immunology
February 2021
Objectives: The role of tumor-associated neutrophils (TANs) in the nodal spread of cancer cells remains unexplored. The present study evaluates the occurrence and clinical significance of human nodal TANs.
Methods: The relevance, derivation, phenotype and interactions of nodal TANs were explored a large immunohistochemical analysis of carcinoma-draining lymph nodes, and their clinical significance was evaluated on a retrospective cohort of oral squamous cell carcinomas (OSCC).
Intraparotid metastasis from lung adenocarcinoma diagnosed by FNAC-Report of a rare case.
Diagn Cytopathol
July 2020
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Metastasis to the parotid gland accounts for 10%-16% of parotid malignancies. Head and neck malignancies constitute the major bulk of metastatic lesions to the parotid. The other common primaries include the breast, kidney, lung, and prostate.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!