Primary manifestations of HIV infection may present as a mononucleosis-like syndrome. Cases have also been reported where it presents with symptoms of encephalitis, meningitis or acute polyneuropathy. When no cause is found for such clinical symptoms, they should suggest the possibility of primary HIV infection even in a patient who is not at risk. HIV antibody will appear in the following weeks and serum studies should be done within the three months that follow. The patient should then be warned that he is contagious. Short term prognostic is usually good. But long term progosis remains uncertain.

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