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Exogenous putrescine plays a switch-like influence on the pH stress adaptability of biofilm-based activated sludge.
Appl Environ Microbiol
July 2024
School of Environmental Science and Engineering, Tianjin University, Tianjin, China.
Article Synopsis
- The study investigates how exogenous putrescine affects microbial community adaptability to pH stress and its role in biofilm formation under different pH conditions.
- Findings indicate that putrescine can enhance biofilm formation in acidic environments while inhibiting it in alkaline conditions due to its protonation and effects on cell membrane permeability.
- This research provides insights into using putrescine to regulate biofilm characteristics, offering potential applications in engineering by controlling microbial behavior based on pH levels.
Resensitizing tigecycline- and colistin-resistant using an engineered conjugative CRISPR/Cas9 system.
Microbiol Spectr
April 2024
Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou, China.
Unlabelled: Tigecycline and colistin were referred to as the "last resort" antibiotics in defending against carbapenem-resistant, Gram-negative bacterial infections, and are currently widely used in clinical treatment. However, the emergence and prevalence of plasmid-mediated (X4) and genes pose a serious threat to the therapeutic application of tigecycline and colistin, respectively. In this research, a tigecycline- and colistin-resistant bacteria resensitization system was developed based on efficient and specific DNA damage caused by Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Associated Protein 9 (Cas9) nucleases.
View Article and Find Full Text PDFTroriluzole inhibits methamphetamine place preference in rats and normalizes methamphetamine-evoked glutamate carboxypeptidase II (GCPII) protein levels in the mesolimbic pathway.
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Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA; Department of Neural Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address:
Riluzole, approved to manage amyotrophic lateral sclerosis, is mechanistically unique among glutamate-based therapeutics because it reduces glutamate transmission through a dual mechanism (i.e., reduces glutamate release and enhances glutamate reuptake).
View Article and Find Full Text PDFFabrication of a Polymeric Inhibitor of Proximal Metabolic Enzymes in Hypoxia for Synergistic Inhibition of Cancer Cell Proliferation, Survival, and Migration.
ACS Appl Mater Interfaces
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Division of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka565-0871, Japan.
Since conventional molecular targeted drugs often result in side effects, the development of novel molecular targeted drugs with both high efficacy and selectivity is desired. Simultaneous inhibition of metabolically and spatiotemporally related proteins/enzymes is a promising strategy for improving therapeutic interventions in cancer treatment. Herein, we report a poly-α-l-glutamate-based polymer inhibitor that simultaneously targets proximal transmembrane enzymes under hypoxia, namely, carbonic anhydrase IX (CAIX) and zinc-dependent metalloproteinases.
View Article and Find Full Text PDFMechanism-Based Design of the First GlnA4-Specific Inhibitors.
Chembiochem
October 2022
Department of Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287, Darmstadt, Germany.
γ-Glutamylamine synthetases are an important class of enzymes that play a key role in glutamate-based metabolism. Methionine sulfoximine (MSO) is a well-established inhibitor for the archetypal glutamine synthetase (GS) but inhibitors for most GS-like enzymes are unknown. Assuming a conserved catalytic mechanism for GS and GS-like enzymes, we explored if subtype-selective inhibitors can be obtained by merging MSO with the cognate substrates of the respective GS-like enzymes.
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