AI Article Synopsis
- The TEMPOJIMS study aims to clarify the role of TMJ surgery through a two-phase preclinical trial involving Black Merino sheep, focusing on TMJ disc evaluation and interposal material comparison.
- Phase 1 reveals significant imaging and histopathologic changes after bilateral discectomy, with body weight effects observed in the first four months post-surgery, while discopexy showed minimal changes.
- The findings highlight the need for better interposal materials to replace the TMJ disc and suggest further exploration into the molecular causes of TMJ cartilage degeneration, marking an advancement in rigorous TMJ research.
Article Abstract
Introduction: The role of temporomandibular joint (TMJ) surgery is not well defined due to a lack of quality randomized controlled clinical trials, comparing different TMJ surgical treatments with medical and placebo interventions. The temporomandibular joint interposal study (TEMPOJIMS) is a rigorous preclinical trial divided in 2 phases. In phase 1 the authors investigated the role of the TMJ disc and in phase 2 the authors evaluated 3 different interposal materials. The present work of TEMPOJIMS - phase 1, aims to evaluate histopathologic and imaging changes of bilateral discectomy and discopexy in Black Merino sheep TMJ, using a high-quality trial following the ARRIVE guidelines.
Material And Methods: This randomized, blinded and controlled preclinical trial was conducted in 9 Black Merino sheep to investigate histopathologic (primary outcome), imaging and body weight (secondary outcomes) changes after bilateral discectomy, discopexy and sham surgery.
Results: Significant changes were noticed in discectomy group, both in imaging and histopathologic analyses. Body weight changes were most pronounced in the discectomy group in the first 4 months after surgery with recovery to baseline weight 6 months after surgery. Discopexy induced nonsignificant changes in histopathologic, imaging and body weight analyses.
Conclusions: This study reinforces the importance of developing an effective interposal material to substitute the TMJ disc and the need to explore the molecular mechanisms that underlie TMJ cartilage degeneration. The study design proposed in TEMPOJIMS represents an important progress towards future rigorous TMJ investigations.
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| http://dx.doi.org/10.1016/j.jcms.2018.01.006 | DOI Listing |
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