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Macrophages in inflammatory skin diseases and skin tumors.
Front Immunol
December 2024
Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Article Synopsis
- - Macrophages are key immune cells that play diverse roles in the body, especially in the skin, which is the largest immune organ and is crucial for studying various skin-related conditions.
- - This review focuses on recent findings about macrophages in inflammatory skin diseases like atopic dermatitis and psoriasis, as well as skin tumors such as melanoma and cutaneous T-cell lymphoma.
- - The goal is to enhance understanding of how macrophages contribute to these diseases and explore potential new treatments targeting them.
Serum Biomarkers IL-6 and HIF-1α in Rosacea: Assessing Their Significance in Disease Pathogenesis and Telangiectasia Formation.
Dermatol Pract Concept
October 2024
Dermatology Clinic, University of Health Sciences, Etlik City Hospital, Ankara, Turkey.
Introduction: Rosacea, a chronic inflammatory disease primarily affecting the central area of the face, is a complex condition whose mechanisms are still not fully understood. However, research has indicated a positive correlation between two molecules: hypoxia-inducible factor-1α (HIF-1α) and interleukin-6 (IL-6). The levels of HIF-1α in rosacea patients have yet to be assessed.
View Article and Find Full Text PDFViral Diversity in Mixed Tree Fruit Production Systems Determined through Bee-Mediated Pollen Collection.
Viruses
October 2024
Agriculture and Agri-Food Canada, London Research and Development Centre, Vineland Research Station, 4902 Victoria Ave N, Vineland Station, ON L0R 2E0, Canada.
Article Synopsis
- Commercial orchards often have mixed species that can be affected by various viruses, with pollen being a significant pathway for virus transmission.
- Metagenomics approaches were used to analyze pollen and bee samples during the blooming season of apricot, cherry, peach, and apple trees, resulting in the detection of 21 unique viruses, including notable ones like prune dwarf virus and prunus necrotic ringspot virus.
- The study revealed a higher complexity of viruses in pollen samples compared to vegetative tissues, highlighting the importance of monitoring pollination ecosystems for better understanding of viral diversity.
Implications of the non-neuronal cholinergic system for therapeutic interventions of inflammatory skin diseases.
Exp Dermatol
October 2024
The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Article Synopsis
- Acetylcholine (ACh) plays crucial roles in both the nervous system and non-neuronal cholinergic systems (NNCS), affecting various physiological functions, particularly in skin cells like keratinocytes and immune cells.
- The NNCS is vital for maintaining skin barrier integrity, wound healing, microcirculation regulation, and controlling inflammation, making it a potential target for therapeutic interventions.
- The review discusses the use of different therapeutic strategies, such as AChE inhibitors and receptor modulators, highlighting the NNCS's connection to skin diseases like psoriasis and acne, while addressing challenges in clinical application and the need for more human studies.
Comparative Analysis of the Cutaneous Microbiome in Psoriasis Patients and Healthy Individuals-Insights into Microbial Dysbiosis: Final Results.
Int J Mol Sci
October 2024
Dermatology Department, Carol Davila University of Medicine and Pharmacy, 030167 Bucharest, Romania.
Psoriasis is one of the most frequent chronic inflammatory skin diseases and exerts a significant psychological impact, causing stigmatization, low self-esteem and depression. The pathogenesis of psoriasis is remarkably complex, involving genetic, immune and environmental factors, some of which are still incompletely explored. The cutaneous microbiome has become more and more important in the pathogenesis of inflammatory skin diseases such as acne, rosacea, atopic dermatitis and psoriasis.
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