AI Article Synopsis
- The process starts with acylating a specific enantiomer of an amine compound using chloroacetyl chloride.
- Next, a reduction step with borane is performed to modify the compound further.
- Finally, aluminum chloride is used as a catalyst to facilitate a cyclization reaction, resulting in the production of enantiopure lorcaserin.
Article Abstract
Acylation of enantiomerically pure (R)-2-(3-chlorophenyl)propan-1-amine using chloroacetyl chloride, followed by borane reduction and aluminum chloride catalyzed cyclization yielded enantiopure lorcaserin.
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| http://dx.doi.org/10.1016/j.bmc.2018.02.038 | DOI Listing |
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