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Vitamin B12-induced acneiform eruption.
Proc (Bayl Univ Med Cent)
September 2024
Department of Dermatology, Baylor Scott and White Medical Center - Temple, Temple, TX, USA.
Cutaneous acneiform eruptions are a side effect of many medications, including vitamin B12 therapy. However, reports of vitamin B12-induced acne are rare. We present a 67-year-old woman with a new diagnosis of pernicious anemia who developed a sudden acneiform eruption on the face after treatment with high-dose vitamin B12.
View Article and Find Full Text PDFTransthyretin Orchestrates Vitamin B12-Induced Stress Resilience.
Biol Psychiatry
January 2025
Institute for Biochemistry and Biophysics, Friedrich Schiller University, Jena, Germany; Institute of Human Genetics, Jena University Hospital, Jena, Germany. Electronic address:
Article Synopsis
- - Chronic stress plays a significant role in mood and anxiety disorders, and previous studies suggest that vitamin B12 may help improve resilience against stress and depression, although the mechanisms behind this connection are still unclear.
- - Researchers used a mouse model to explore how vitamin B12 affects gene expression related to stress resilience, discovering that Ttr (transthyretin) is a key target for vitamin B12 and is linked to depression-like behaviors.
- - The study found that vitamin B12 reduces DNA methylation in the Ttr promoter, providing a causal link between vitamin B12, Ttr, and stress-related behaviors, which suggests that dietary interventions could be beneficial for mood disorders.
Parental dietary vitamin B12 causes intergenerational growth acceleration and protects offspring from pathogenic microsporidia and bacteria.
iScience
July 2024
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
The parental environment of can have lasting effects on progeny development and immunity. Vitamin B12 exposure in has been shown to accelerate development and protect against pathogenic bacteria. Here, we show that parental exposure to dietary vitamin B12 or vitamin B12-producing bacteria results in offspring with accelerated growth that persists for a single generation.
View Article and Find Full Text PDFHemolytic Anemia and Pancytopenia Secondary to Vitamin B12 Deficiency: Evaluation and Clinical Significance.
Cureus
March 2024
Internal Medicine, Northwell Health, New York, USA.
Severe vitamin B12 deficiency presents a diagnostic challenge due to its diverse clinical manifestations, which can mimic serious hematologic disorders such as thrombotic thrombocytopenic purpura (TTP) or leukemia. The case we present here illustrates the unique characteristics of severe B12 deficiency, highlighting key differentiators from other conditions, including decreased reticulocyte counts and markedly elevated lactate dehydrogenase levels indicative of suppressed erythropoiesis. Advanced cobalamin deficiency affects all cell lines, leading to peripheral pancytopenia.
View Article and Find Full Text PDFVitamin B12 Deficiency Disguised As Hemolytic Anemia: A Case Presentation.
Cureus
January 2024
Pediatric Hematology and Oncology, University of Florida, Ascension Sacred Heart, Pensacola, USA.
This case report describes an 18-month-old male presenting with hemolytic anemia and lethargy, who was ultimately diagnosed with severe vitamin B12 deficiency. The child exhibited global developmental delays, including a lack of speech and walking skills. Initially suspected as intravascular hemolytic anemia, the normal reticulocyte count led to further investigation, which revealed low cobalamin (vitamin B12) levels.
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