AI Article Synopsis
- Epigenetic modifications play a critical role in cancer biology, highlighting that cancer isn't just a genetic issue but also involves changes in gene regulation.
- These changes contribute to the diversity of gene expression across different tissues and are linked to various disease stages, prompting new strategies for diagnosis and treatment.
- Studies on oral cancer show that its development is influenced by both epigenetic changes and genetic factors, with this review focusing on significant epigenetic alterations that could serve as potential therapeutic targets.
Article Abstract
Epigenetic modifications have emerged into one of the cancer hallmarks, replacing the concept of malignant pathologies as being solely genetic-based conditions. The epigenetic landscape is responsible for normal development but also for the heterogeneity among tissues in terms of gene expression patterns. Dysregulation in these mechanisms has been associated with disease stage, and increased attention is now granted to cancer in order to take advantage of these modifications in terms of novel therapeutic strategies or diagnosis/prognosis tools. Oral cancer has also been subjected to epigenetic analysis with numerous studies revealing that the development and progression of this malignancy are partially induced by an altered epigenetic substrate together with genetic alterations and prolonged exposure to environmental risk factors. The present review summarizes the most important epigenetic modifications associated with oral cancer and also their potential to be used as new therapeutic targets.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877531 | PMC |
| http://dx.doi.org/10.3390/ijms19030670 | DOI Listing |
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