AI Article Synopsis
- Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease linked to immune regulation issues, particularly involving T-regulatory cells that produce anti-inflammatory cytokines.
- A study with 25 newly diagnosed JIA patients showed a higher proportion of T-regulatory cells compared to a control group of 17 healthy children.
- However, levels of the anti-inflammatory cytokines IL-10 and TGF-β1 were similar between both groups, suggesting they are not useful as biomarkers for JIA diagnosis.
Article Abstract
Background: Juvenile idiopathic arthritis (JIA) is a chronic, heterogenous inflammatory disease of unclear pathogenesis. JIA is hypothesized to be linked to a defective immune regulation. Anti-inflammatory cytokines belong to the best known regulatory factors. T-regulatory cells are a crucial cellular component of immune tolerance. One of their functions is synthesis of interleukin 10 (IL-10) and transforming growth factor beta1 (TGF-β1). The aim of this study was to determine the proportion of T-regulatory cells (CD4CD25FOXP3) in peripheral blood, and serum levels of TGF-β1 and IL-10 in patients with JIA.
Methods: The study included 25 patients with newly diagnosed JIA: oligoarthritis (n=17) and polyarthritis (n=8). The control group was comprised of 17 healthy children. CD4CD25FOXP3 T cells in peripheral blood were quantified by means of three-color flow cytometry. Serum concentrations of TGF-β1 and IL-10 were estimated with ELISA.
Results: The proportion of peripheral CD4CD25FOXP3 cells in patients with JIA was significantly higher than in the controls (p=0.04). The two groups did not differ significantly in terms of their TGF-β1 and IL-10 concentrations.
Conclusions: At the time of diagnosis, children with JIA presented with an elevated proportion of T-regulatory cells (CD4CD25FOXP3) in peripheral blood. Anti-inflammatory cytokines, IL-10 and TGF-β1, are not upregulated in the serum of patients with JIA, and therefore should not be considered as biomarkers of this condition.
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| http://dx.doi.org/10.18388/abp.2017_2308 | DOI Listing |
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