AI Article Synopsis
Article Abstract
Recently, it has been reported that deregulation of the receptor activator of NFkB ligand (RANKL)/RANK signaling axis results in salivary gland tumor development in a mouse transgenic model. The aim of this study was to ascertain RANKL and RANK protein expression in a series of primary parotid gland carcinomas and to correlate it with clinicopathologic parameters. Formalin-fixed paraffin-embedded tumor samples from 46 consecutive cases of parotid gland carcinoma were selected for this study. For comparison, we examined a group of 40 randomly chosen parotid gland adenomas, including 20 pleomorphic adenomas, 10 myoepitheliomas, and 10 Warthin tumors. Immunohistochemical analysis for RANK and RANKL was conducted on tissue microarrays. Overall, 33 carcinomas (71.7%) were scored as positive for RANK and 25 (54.3%) for RANKL. The expression of both RANK and RANKL was significantly higher in carcinomas than in adenomas as only 6 (15%) adenomas were positive for RANK, and RANKL was negative in all benign tumors (P<0.001 for both, Fisher exact test). Some histologic types, including salivary duct carcinoma, mucoepidermoid carcinoma, and carcinoma ex-pleomorphic adenoma presented a high frequency of RANK and RANKL expression. No significant correlation was observed between RANK/RANKL expression and clinical parameters. Our study indicates that the expression of RANK and RANKL in parotid gland neoplasms is associated with the acquisition of a malignant phenotype and this pathway may represent an attractive therapeutic target in patients with parotid gland carcinomas.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/PAI.0000000000000465 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Diagnostic Values of Fine Needle Aspiration Cytology and Frozen Section in Management of Parotid Tumors.
Ear Nose Throat J
December 2024
Department of Otolaryngology-Head and Neck Surgery, Bursa Uludag University, Faculty of Medicine, Bursa, Turkey.
This study aims to investigate the diagnostic values of fine needle aspiration cytology (FNAC) and frozen section (FS) in evaluating parotid gland masses subjected to parotidectomy. A retrospective analysis of data from 274 patients who underwent parotidectomy for parotid gland masses was performed at the Department of Otolaryngology of the University Hospital between 2013 and 2019. We compared the preoperative FNAC and intraoperative FS records with the definitive histopathological diagnoses obtained from the surgical resection specimens.
View Article and Find Full Text PDFImpact of annotation imperfections and auto-curation for deep learning-based organ-at-risk segmentation.
Phys Imaging Radiat Oncol
October 2024
Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Radiation Oncology, De Boelelaan 1117, Amsterdam, the Netherlands.
Background And Purpose: Segmentation imperfections (noise) in radiotherapy organ-at-risk segmentation naturally arise from specialist experience and image quality. Using clinical contours can result in sub-optimal convolutional neural network (CNN) training and performance, but manual curation is costly. We address the impact of simulated and clinical segmentation noise on CNN parotid gland (PG) segmentation performance and provide proof-of-concept for an easily implemented auto-curation countermeasure.
View Article and Find Full Text PDF[Effect of retrograde dissection of the facial nerve along the mandibular margin on postoperative quality of life in patients with benign superficial parotid tumors].
Shanghai Kou Qiang Yi Xue
October 2024
Department of Stomatology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences(Qingdao Central Hospital). Qingdao 266042, Shandong Province, China. E-mail:
Purpose: To assess the impact of retrograde dissection of the facial nerve along the mandibular margin on the postoperative quality of life in patients with benign superficial parotid tumors.
Methods: One hundred and sixteen patients who underwent surgical treatment for benign superficial parotid tumors at Qingdao Central Hospital from January 2020 to January 2023 were involved. The patients were randomly allocated into two groups, with 58 patients in each group using the touch ball method.
Periorbital Microcystic Adnexal Carcinoma With Distant Metastases.
Ophthalmic Plast Reconstr Surg
December 2024
Department of Ophthalmology, Liverpool Hospital, Liverpool, New South Wales.
Purpose: Microcystic adnexal carcinoma (MAC) is a locally aggressive adnexal carcinoma of the head and neck, which has a high tendency for recurrence. MAC rarely has distant metastasis, with only one previously reported case originating from the periorbital region. We present a patient with periorbital MAC with distant metastasis and a review of all reported patients with metastatic disease.
View Article and Find Full Text PDFPurpose: There is no current standard treatment regimen for carcinoma ex pleomorphic adenoma (CXPA) of the lacrimal gland. Neoadjuvant intraarterial cytoreductive chemotherapy (IACC) followed by multimodal therapy has achieved good locoregional control in adenoid cystic carcinoma of the lacrimal gland. We reviewed our experience with neoadjuvant IACC followed by multimodal therapy for CXPA of the lacrimal gland.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!