AI Article Synopsis
- G6PD deficiency can lead to serious complications like acute intravascular hemolysis and acute kidney injury (AKI), but there’s limited information on rhabdomyolysis and myoglobinuria in these patients, especially in children.
- An 11-year-old girl from South India showed signs of severe anemia and anuric AKI after a fever, with tests revealing hemolysis and rhabdomyolysis, confirmed by myoglobin deposits in her kidneys.
- The girl was treated successfully with dialysis and blood transfusions, and follow-up tests confirmed she had severe G6PD deficiency, suggesting that myoglobinuria might affect kidney health during acute hemolytic crises in these patients.
Article Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency leading to acute intravascular haemolysis and acute kidney injury (AKI) is a known clinical presentation. However, there is a paucity of information regarding the occurrence of rhabdomyolysis and myoglobinuria in G6PD-deficient individuals, especially children. An 11-year-old south Indian Tamil girl presented with severe anaemia and anuric AKI following a short febrile illness. Investigations demonstrated evidence of intravascular haemolysis and rhabdomyolysis, and on histopathology myoglobin deposits (casts) were detected in the renal tubules. She was successfully managed with repeated sessions of haemodialysis and blood transfusions. Follow-up estimation of G6PD levels after 3 months confirmed severe G6PD deficiency (0.003 nkat/g haemoglobin). Although there are anecdotal reports of myoglobinuria in G6PD-deficient individuals, the occurrence of severe anuric AKI in this clinical setting has not been reported. It can be speculated that myoglobinuria (in addition to haemoglobinuria) can contribute towards jeopardising renal function in G6PD deficiency-related acute haemolytic crisis.
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| http://dx.doi.org/10.1080/20469047.2018.1439804 | DOI Listing |
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