Antimalarial activity of against .

J Parasit Dis

1Biochemistry and Molecular Biology Laboratory, Post Graduate Department of Botany, Utkal University, Vani Vihar, Bhubaneswar, Odisha 751004 India.

Published: March 2018

Malaria is one of the most prevalent vector borne infectious disease and a serious global health problem in the world. Treatment for malaria is commonly inadequate due to the lack of quality assured limited number of effective drugs, underline how important it is to discover new antimalarial plants from number of natural sources. In the present study, the efficacy of antimalarial activity was studied by taking six various (n-hexane, chloroform, petroleum ether, ethanol, methanol and aqueous) organic leaf extracts of (Clarke) Pamp. against malarial parasite . Promising antiplasmodial activity was found in all tested extracts; however, maximum 50% inhibitory concentration (IC) values were noticed after 32 h of incubation, which is 5.76 ± 0.82, 7.09 ± 1.09, 9.88 ± 1.13, 10.24 ± 1.52, 11.37 ± 1.77 and 50.15 ± 6.16 µg/ml in methanol, chloroform, n-hexane, petroleum ether, ethanol and aqueous extracts, respectively. In conclusion, leaf extract possesses antiplasmodial activity which may be used as a potent plant-based antimalarial drug in the future by investigating the hidden phytochemical/(s).

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825358PMC
http://dx.doi.org/10.1007/s12639-017-0956-9DOI Listing

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