A benign appearing ECG is found to contain subtle clues suggestive of underlying structural heart disease.
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Therapeutic Targeting of the Leukaemia Microenvironment.
Int J Mol Sci
June 2021
Leukaemia Translational Research Laboratory, Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA 6009, Australia.
In recent decades, the conduct of uniform prospective clinical trials has led to improved remission rates and survival for patients with acute myeloid leukaemia and acute lymphoblastic leukaemia. However, high-risk patients continue to have inferior outcomes, where chemoresistance and relapse are common due to the survival mechanisms utilised by leukaemic cells. One such mechanism is through hijacking of the bone marrow microenvironment, where healthy haematopoietic machinery is transformed or remodelled into a hiding ground or "sanctuary" where leukaemic cells can escape chemotherapy-induced cytotoxicity.
View Article and Find Full Text PDFPhosphorylation and Proteolytic Cleavage of Notch in Canonical and Noncanonical Notch Signaling.
Adv Exp Med Biol
March 2020
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
The Notch signaling pathway seems deceptively simple, with its key feature being a direct connection between extracellular signal and transcriptional output without the need for an extended chain of protein intermediaries as required by so many other signaling paradigms. However, this apparent simplicity hides considerable complexity. Consistent with its central role in many aspects of development, Notch signaling has an extensive collection of mechanisms that it employs alongside of its core transcriptional machinery.
View Article and Find Full Text PDFA Snapshot of the Molecular Biology of Notch Signaling: Challenges and Promises.
Adv Exp Med Biol
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Department of Dermatology, The Saarland University Hospital, Homburg, Germany.
Evolutionary conserved Notch signaling is of high importance for embryogenesis and adult tissues, representing one of the most fascinating pathways that regulate key cell fate decisions and other core processes. This chapter gives a short introduction to the first volume of the book entitled Notch Signaling in Embryology and Cancer, that is intended to provide both basic scientists and clinicians who seek today`s clearest understanding of the molecular mechanisms that mediate Notch signaling with an authoritative day-to-day source. On a first look, Notch signaling, that first developed in metazoans and that was first discovered in a fruit fly, seems fallaciously simple, with its key feature being a direct link between an extracellular signal and transcriptional output without the requirement of an extended chain of protein intermediaries as needed by the majority of other signaling pathways.
View Article and Find Full Text PDFA benign appearing ECG is found to contain subtle clues suggestive of underlying structural heart disease.
View Article and Find Full Text PDFThe role of extracellular matrix in vascular branching morphogenesis.
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INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire, C3M, Université de Nice-Sophia-Antipolis, Nice, France.
Angiogenesis requires the development of a hierarchically branched network of vessels, which undergoes radial expansion and anastomosis to form a close circuit. Branching is achieved by coordinated behavior of endothelial cells that organize into leading "tip" cells and trailing "stalk" cells. Such organization is under control of the Dll4-Notch signaling pathway, which sets a hierarchy in receptiveness of cells to VEGF-A.
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