AI Article Synopsis
- A meta-analysis was conducted to assess the diagnostic accuracy of magnifying narrow-band imaging (ME-NBI) for identifying gastric cancerous lesions, showing varying results in previous trials.
- Nine studies with a total of 5,398 lesions were analyzed, revealing pooled sensitivity and specificity rates of 88% and 96%, respectively, indicating that ME-NBI is effective for differentiating between cancerous and noncancerous gastric lesions.
- The analysis also highlighted consistent high accuracy in identifying small lesions (≤10 mm) and varied accuracy between studies that examined resected versus biopsied specimens.
Article Abstract
Background: Previous clinical trials have demonstrated the diagnostic accuracy of magnifying narrow-band (ME-NBI) for gastric cancerous lesions, but the results are inconsistent. The purpose of this meta-analysis is to investigate the accuracy of ME-NBI in distinguishing between cancerous and noncancerous gastric lesions.
Methods: Systematic literature searches were conducted until October 2016 in PubMed, Embase by 2 independent reviewers. Meta-analysis was performed to calculate the pooled sensitivity, specificity. Two authors independently evaluated studies for inclusion, rated methodological quality, and abstracted relevant data. Meta-analytic method was used to construct summary receiver operating characteristic curves, and pooled sensitivity, specificity were calculated.
Results: Nine studies enrolling 5398 lesions were included. The pooled sensitivity, specificity were 88% (95% confidence interval [CI]: 78-93%), 96% (95% CI: 91-98%), respectively. The area under the curve (AUC) was 0.97. There was a large heterogeneity between the included studies. Studies with lesions ≤ 10 mm still had a high pooled sensitivity of 81% (95% CI: 73-90%) and specificity of 97% (95% CI: 95-100%). Studies which analyzed resected specimens had a sensitivity of 91% (95 CI: 82-99%) and specificity of 88% (95% CI: 83-94%), and studies which analyzed biopsied specimens had a sensitivity of 85% (95 CI: 74-96%) and specificity of 99% (95% CI: 98-99%).
Conclusions: ME-NBI is highly accurate and consistent to distinguish between gastric cancerous and noncancerous lesions.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851730 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000009780 | DOI Listing |
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