Three new indole diterpenes, penicilindoles A-C (1-3), were isolated from the mangrove-derived fungus Eupenicillium sp. HJ002. Their planar structures and absolute configurations were determined by interpretation of NMR spectroscopic data, HR-ESIMS, and X-ray diffraction analysis using Cu Kα radiation. The cytotoxic and antibacterial activities were evaluated in vitro; penicilindole A (1) showed cytotoxic activity against human A549 and HepG2 cell lines with IC values of 5.5 and 1.5 μM, respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jnatprod.7b00673 | DOI Listing |
Publication Analysis
Top Keywords
penicilindoles a-c
8
indole diterpenes
8
mangrove-derived fungus
8
fungus eupenicillium
8
eupenicillium hj002
8
a-c cytotoxic
4
cytotoxic indole
4
diterpenes mangrove-derived
4
hj002 three
4
three indole
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!