Obesity is associated with an increased risk of premature death and represents a fast growing worldwide health problem. Although it has been long recognized that obesity is associated with an impaired insulin sensitivity, significantly increases the risk of developing type 2 diabetes, dyslipidemia, fatty liver disease, hypertension, cardiovascular disease and certain types of cancers, a subgroup of obese individuals called metabolic healthy obese seems to be protected from metabolic and cardiovascular obesity comorbidities. This article focuses on potential mechanisms underlying the healthy obese phenotype (protection against development of hepatic steatosis, inflammation of visceral adipose tissue, ectopic fat deposition and adipose tissue dysfunction) and on clinical relevance of this interesting subgroup of obese individuals. Additionally, definition, epidemiology and stability of healthy obese phenotype are discussed.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Prevalence of some cardiovascular risk factors: obesity, hypertension, and smoking among medical students.
Crit Pathw Cardiol
January 2025
Internal Medicine Department, College of Medicine, King Faisal University, Alhasa, Saudi Arabia.
Introduction: Cardiovascular diseases (CVDs) are the principal cause of worldwide mortality, with 17.9 million deaths reported in 2019. In Saudi Arabia, CVDs account for 42% of all deaths, occurring on average 10 years earlier than in Western populations.
View Article and Find Full Text PDFInteraction between breastfeeding duration and an obesity genetic risk score to predict body fat composition in European adolescents: The HELENA study.
Pediatr Obes
January 2025
Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragón (IA2), University of Zaragoza, Zaragoza, Spain.
Background: Although the genetic interplay with the environment has a major impact on obesity development, little is known on whether breastfeeding could modulate the genetic predisposition to obesity.
Objectives: To investigate whether breastfeeding attenuates the effect of an obesity genetic risk score (GRS) on adiposity in European adolescents.
Methods: Totally 751 adolescents from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study were included, divided according to breastfeeding status into never breastfed, 1-3 months and ≥4 months.
Lifestyle changes among older adults during and after COVID-19 pandemic in Lithuania.
Front Public Health
January 2025
Department of Health Management, Faculty of Public Health, Lithuanian University of Health Sciences, Kaunas, Lithuania.
The Aim Of This Study: to analyze lifestyle changes among older adults during and after COVID-19 pandemic in Lithuania, with a particular focus on eating habits, physical activity, social engagement and harmful habits.
Methods: The representative sample of Lithuanian population over 65 years old (1,503 individuals) was involved in the questionnaire survey, performed in January 2024.
Results: Most of the eating habits and the body weight of the older adults did not change during the COVID-19 pandemic in Lithuania.
Relationship between maternal pre-pregnancy BMI and neonatal birth weight in pregnancies with gestational diabetes mellitus: a retrospective cohort study.
Front Med (Lausanne)
January 2025
Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Aim: The aim of this study was to explore the association between maternal pre-pregnancy body mass index (BMI) and neonatal birth weight in pregnancies with gestational diabetes mellitus (GDM).
Methods: This was a retrospective cohort study conducted between January 2019 and June 2020 at a university hospital in Fuzhou, China.
Results: Pre-pregnancy BMI was used to categorize 791 pregnant women as underweight (3.
Predictive Value of the Triglyceride-Glucose Index for Metabolic-Associated Fatty Liver Disease in Individuals with Different Metabolic Obese Phenotypes.
Diabetes Metab Syndr Obes
January 2025
Physical Examination Center, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
Objective: To investigate the relationship between triglyceride-glucose (TyG) index and metabolic-associated fatty liver disease (MAFLD), and to evaluate the predictive value of the TyG index for MAFLD in individuals with different metabolic obese phenotypes. The aim is to provide a novel approach for the screening and early diagnosis of MAFLD in the general population.
Methods: A total of 2614 subjects were recruited and classified into four categories of metabolic obese phenotypes based on their body mass index (BMI) and metabolic status.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!