Using a functional proliferation reporter we identified quiescent tumor propagating cancer cells (TPCs) in intact squamous cell carcinomas, and found that TGFβ signaling controls their reversible entry into a growth arrested state, which protects TPCs from chemotherapy. TPCs with compromised TGFβ/Smad signaling can't enter quiescence and subsequently die from chemotherapy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821413 | PMC |
| http://dx.doi.org/10.1080/23723556.2017.1413495 | DOI Listing |
Publication Analysis
Top Keywords
cancer cells
8
cellular quiescence
4
quiescence tgfβ
4
tgfβ protects
4
protects cancer
4
cells chemotherapy
4
chemotherapy functional
4
functional proliferation
4
proliferation reporter
4
reporter identified
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!