Using a functional proliferation reporter we identified quiescent tumor propagating cancer cells (TPCs) in intact squamous cell carcinomas, and found that TGFβ signaling controls their reversible entry into a growth arrested state, which protects TPCs from chemotherapy. TPCs with compromised TGFβ/Smad signaling can't enter quiescence and subsequently die from chemotherapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821413 | PMC |
| http://dx.doi.org/10.1080/23723556.2017.1413495 | DOI Listing |
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