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Single-arm multicenter phase II study on aggressive local consolidative therapy in combination with systemic chemotherapy for stage IV non-small cell lung carcinoma with oligometastases: CURE-OLIGO (TORG1529).
Radiat Oncol
January 2025
Department of Respiratory Medicine and Medical Oncology, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.
Introduction: Stage IV non-small cell lung carcinoma (NSCLC) with oligometastases is potentially curable by radical treatment. This study aimed to evaluate the efficacy and safety of chemoradiotherapy (CRT) for thoracic disease, including the primary lesion and lymph node metastases, combined with local consolidative therapy (LCT) for oligometastases.
Methods: This was a multicenter Phase II trial for patients with Stage IV NSCLC with oligometastases for whom CRT for thoracic disease was feasible.
Analysis of inoculation strategies during COVID-19 pandemic with an agent-based simulation approach.
Comput Biol Med
January 2025
Department of Industrial Engineering, Izmir University of Economics, Izmir, 35330, Türkiye. Electronic address:
Background: The severity of recent Coronavirus (COVID-19) pandemics has revealed the importance of development of inoculation strategies in case of limited vaccine availability. Authorities have implemented inoculation strategies based on perceived risk factors such as age and existence of other chronic health conditions for survivability from the disease. However, various other factors can be considered for identifying the preferred inoculation strategies depending on the vaccine availability and disease spread levels.
View Article and Find Full Text PDFElectrolyte Decoupling Strategy for Metal Oxide-Based Zinc-ion Batteries Free of Crosstalk Effect.
Angew Chem Int Ed Engl
January 2025
Tsinghua University, Tsinghua Shenzhen International Graduate School, CHINA.
The crosstalk of transition metal ions between the metal oxide cathode and Zn anode restricts the practical applications of aqueous zinc-ion batteries (ZIBs). Herein, we propose a decoupled electrolyte (DCE) consisting of a nonaqueous-phase (N-phase) anolyte and an aqueous-phase (A-phase) catholyte to prevent the crosstalk of Mn2+, thus extending the lifespan of MnO2-based ZIBs. Experimental measurements and theoretical modelling verify that trimethyl phosphate (TMP) not only synergistically works with NH4Cl in the N-phase anolyte to enable fast Zn2+ conduction while block Mn2+ diffusion toward anode, but also modifies the Zn2+ solvation structure to suppress the dendrite formation and corrosion on Zn anode.
View Article and Find Full Text PDFhsa-mir-483-3p modulates delayed breast cancer recurrence.
Sci Rep
January 2025
Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University, Seoul, 06974, South Korea.
Patients with estrogen receptor-positive breast cancer undergoing continuous adjuvant hormone therapy often experience delayed recurrence with tamoxifen use, potentially causing adverse effects. However, the lack of biomarkers hampers patient selection for extended endocrine therapy. This study aimed to elucidate the molecular mechanisms underlying delayed recurrence and identify biomarkers.
View Article and Find Full Text PDFMolecular basis of proton sensing by G protein-coupled receptors.
Cell
December 2024
Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143, USA; Chan Zuckerberg Biohub, San Francisco, CA 94148, USA; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94115, USA. Electronic address:
Three proton-sensing G protein-coupled receptors (GPCRs)-GPR4, GPR65, and GPR68-respond to extracellular pH to regulate diverse physiology. How protons activate these receptors is poorly understood. We determined cryogenic-electron microscopy (cryo-EM) structures of each receptor to understand the spatial arrangement of proton-sensing residues.
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