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Recording Lineage History with Cellular Barcodes in the Mammary Epithelium and in Breast Cancer.
Adv Exp Med Biol
January 2025
Laboratory of Genetics and Developmental Biology, Institut Curie, INSERM U934, CNRS UMR3215, Paris, France.
Lineage tracing methods have extensively advanced our understanding of physiological cell behaviour in vivo and in situ and have vastly contributed to decipher the phylogeny and cellular hierarchies during normal and tumour development. In recent years, increasingly complex systems have been developed to track thousands of cells within a given tissue or even entire organisms. Cellular barcoding comprises all techniques designed to genetically label single cells with unique DNA sequences or with a combination of fluorescent proteins, in order to trace their history and lineage production in space and time.
View Article and Find Full Text PDFChapter 9: INDICATIONS FOR TREATMENT.
Ann Endocrinol (Paris)
January 2025
Endocrinology, Diabetology and Nutrition Department, CHU Larrey, 24 chemin de Pouvourville, TSA 30030, 31059 Toulouse, France. Electronic address:
The choice of therapeutic method for the management of primary hyperparathyroidism depends on the severity of the disease and its complications at the time of diagnosis, the specific situation of each patient and his/her natural history, and assessment of the risk/benefit ratio for each method (surgery, local destruction or drugs). This chapter summarizes the indications for the treatment of primary hyperparathyroidism, based on the international literature available as of December 31, 2023.
View Article and Find Full Text PDFCan microbiota gut-brain axis reverse neurodegenerative disorders in human?
Ageing Res Rev
January 2025
Medical Science and Technology Innovation Center, Shandong Key Laboratory of Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, Shandong 250117, P R China; School of Medicine and Allied Health Sciences, University of The Gambia; Department of Medical Microbiology, Central South University Changsha, Hunan Provinces, China. Electronic address:
The trillions of microbial populations residing in the gut have recently shown that they can be used as a remedy for various diseases. The gut microbiota-brain-axis interface is one unique pathway that the microbiota demonstrates its medicinal value. This medicinal value is further seen when there is a decline in gut microbial diversity (dysbiosis).
View Article and Find Full Text PDFHistorical and Contemporary Perspectives: Metaphorical Significance of Tooth Extraction in Lithographs and Postcards in the 19th and 20th Centuries in Their Specific Socio-Historical Context.
J Hist Dent
January 2025
Founding member of "Arbeitskreis für die Geschichte der Zahnheilkunde" - Chapter of Deutsche Gesellschaft für Zahn-Mund und Kieferheilkunde - DGZMK (German Society of the History of Dentistry).
In historical illustrations and caricatures, the extraction of a tooth served as a powerful metaphor and threatening gesture that extended far beyond the medical context. This article examines the symbolic significance of this dental procedure and the extracted tooth as an expression of loss, disempowerment, and territorial dispossession. The comparison covers a wide range of visual representations from the French Revolution (1789-1799), the French July Revolution (1830), the Crimean War (1853-1856), the Austro-Prussian War (1866), the Franco-Prussian War (1870/71), to the First (1914-1918) and Second (1939-1945) World Wars and places them in their respective historical contexts.
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