Activities of daily living (ADL) and state of incontinence in 2,567 elderly community residents aged 65 years and over, living in Koganei City (a suburb of Tokyo) were longitudinally investigated through two mail surveys at the beginning and end of a five-year period. At the entry, only 6% of total subjects were classified as low ADL, 3% as incontinent. 30% of the low ADL were classified as incontinent. While the majority of the high ADL and the non-incontinent subjects maintained their conditions during the 5-year period, 66% of the low ADL, 70% of the incontinent, and 81% of the low ADL accompanied by incontinence died during the 5-year period. These mortality rates in low ADL and/or incontinent subjects were 2 times higher than the age-sex standardized mortality rate in the population investigated.
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http://dx.doi.org/10.1016/0167-4943(86)90022-1 | DOI Listing |
Clin Rheumatol
January 2025
Department of Public Health, University of Murcia, Campus de Ciencias de la Salud, Murcia, 30120, Spain.
Introduction: Therapeutic drug monitoring (TDM) in inflammatory rheumatic diseases (RMDs) is gaining interest. However, there are unresolved questions about the best practices for implementing TDM effectively in clinical settings.
Objective: The primary objective of this study was to evaluate whether early TDM of adalimumab predicts drug survival at 52 weeks in patients with RMDs.
Chem Commun (Camb)
January 2025
School of Marine Science and Engineering, Hainan University, Haikou, China.
Severe photogenerated charge carrier recombination involved in photocatalytic CO reduction leads to low photocatalytic efficiency. Here we demonstrate that a chiral hierarchical structure could facilitate charge separation in BiOBr, thus suppressing charge recombination and enhancing photocatalytic performance. Chiral helical flower-like BiOBr nanospheres were prepared a D/L-sorbitol-assisted hydrothermal process, exhibiting a 1.
View Article and Find Full Text PDFJAMA Health Forum
January 2025
Department of Internal Medicine, University of Michigan, Ann Arbor.
Importance: The Affordable Care Act (ACA) expanded Medicaid and Marketplace insurance to nonelderly adults in 2014, but whether these policies improved outcomes later in life is unknown.
Objective: To examine whether exposure to ACA expansions during middle age (50-64 years) was associated with changes in health, utilization, and spending after these adults entered Medicare at 65 years of age.
Design, Setting, And Participants: This serial analysis of the Health and Retirement Study cohort linked to Medicare enrollment and claims data from January 1, 2010, to December 31, 2018.
Future Med Chem
January 2025
Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
Aim: New phenyldiazene scaffold-linked heterocyclic pyrazole, pyrimidinone, pyrimidinthione, and/or triazine rings have been developed and synthesized.
Methods & Results: Cytotoxicity of our derivatives was estimated on four cancer and VERO normal cell lines targeting EGFR (epidermal growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) enzymes. Our new derivatives selectively inhibited both VEGFR-2 and EGFR as they have the essential structural requirements for inhibitors of both receptors.
Lancet Reg Health West Pac
January 2025
Nossal Institute for Global Health, School of Population and Global Health, The University of Melbourne, 32 Lincoln Square, Carlton, 3053, Australia.
Background: There are few studies comparing health status trends among middle-aged and older adults in countries currently experiencing a rapid demographic and economic transition in the Asia-Pacific, relative to their high-income regional counterparts. This study investigates trends in functional limitations among individuals aged 45 years and above in six major Asia-Pacific countries, ranging from middle- to high-income, from 2001 to 2019 and examines disparities across socioeconomic and demographic sub-groups.
Methods: Data on 778,507 individuals from seven surveys in three high-income countries (Australia, Japan, South Korea) and three middle-income countries (China, Indonesia, and India) were used.
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