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Vaccinating for natural killer cell effector functions. | LitMetric

AI Article Synopsis

  • Vaccination has significantly lowered global death rates and helped eradicate infectious diseases, but future successes rely on creating better vaccines, finding effective dosing methods, and refining adjuvants.
  • NK (natural killer) cells play a crucial role in the immune response, showing rapid reactions during primary infections, as well as features that blend innate and adaptive immunity, especially after vaccination.
  • The activation of NK cells through cytokines from myeloid cells is vital for enhancing their function and memory cell formation, highlighting their potential in improving vaccine efficacy and adjuvant development.

Article Abstract

Vaccination has proved to be highly effective in reducing global mortality and eliminating infectious diseases. Building on this success will depend on the development of new and improved vaccines, new methods to determine efficacy and optimum dosing and new or refined adjuvant systems. NK cells are innate lymphoid cells that respond rapidly during primary infection but also have adaptive characteristics enabling them to integrate innate and acquired immune responses. NK cells are activated after vaccination against pathogens including influenza, yellow fever and tuberculosis, and their subsequent maturation, proliferation and effector function is dependent on myeloid accessory cell-derived cytokines such as IL-12, IL-18 and type I interferons. Activation of antigen-presenting cells by live attenuated or whole inactivated vaccines, or by the use of adjuvants, leads to enhanced and sustained NK cell activity, which in turn contributes to T cell recruitment and memory cell formation. This review explores the role of cytokine-activated NK cells as vaccine-induced effector cells and in recall responses and their potential contribution to vaccine and adjuvant development.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822400PMC
http://dx.doi.org/10.1002/cti2.1010DOI Listing

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