AI Article Synopsis
- - This study aimed to evaluate the effectiveness of circulating tumor cells (CTCs) in diagnosing ovarian cancer, especially since there is no effective screening test available.
- - In a group of 61 women suspected of having ovarian tumors, nearly half were diagnosed with cancer, and CTC counts in these patients were found to be significantly higher than in those with benign tumors.
- - The results indicate that CTC counts (specifically DAPI+/E&M+/CD45-/HE4+) have a sensitivity of 73.3%, outperforming the traditional CA125 test, especially in patients with elevated CA125 levels.
Article Abstract
Lacking a satisfactory screening test, ovarian cancer is frequently diagnosed at a late stage, leading to poor patient outcomes. This study investigated the diagnostic value of circulating tumor cells (CTCs) in peripheral blood from patients with suspected ovarian tumors. Sixty-one women suspected of having an ovarian mass were prospectively enrolled in this study. CTCs were identified and counted using microfluidic isolation and immunofluorescent staining of CD45, HE4, and epithelial and mesenchymal (E&M) markers (epithelial cell adhesion molecule, cytokeratins, and vimentin). Thirty (49%) of the patients were diagnosed with ovarian cancer. DAPI+/E&M+/CD45-/HE4+ CTC counts were higher in these patients than in patients with benign tumors ( = 0.016). The receiver operating characteristic (ROC) curve showed that the sensitivity of CTCs was 73.3%, which was superior to that of CA125 (56.7%). In patients with elevated CA125 levels (≥35 U/ml), CTC counts still showed good specificity (86.7%). Our findings suggest the DAPI+/E&M+/CD45-/HE4+ CTC count is a useful diagnostic indicator in patients with suspected ovarian cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800921 | PMC |
| http://dx.doi.org/10.18632/oncotarget.23943 | DOI Listing |
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