AI Article Synopsis
- Scientists found that a special type of tiny RNA called miRNA can control other RNA messages in the body, but some strong connections can cause the miRNA to get destroyed instead.
- They studied how this works in zebrafish and mice, discovering that a specific RNA can change how these animals behave.
- When they changed the part of the RNA that connects with miRNA in mice, it messed up their movement and learning because the miRNA couldn't do its job properly.
Article Abstract
microRNAs (miRNAs) repress target transcripts through partial complementarity. By contrast, highly complementary miRNA-binding sites within viral and artificially engineered transcripts induce miRNA degradation in vitro and in cell lines. Here, we show that a genome-encoded transcript harboring a near-perfect and deeply conserved miRNA-binding site for miR-29 controls zebrafish and mouse behavior. This transcript originated in basal vertebrates as a long noncoding RNA (lncRNA) and evolved to the protein-coding gene NREP in mammals, where the miR-29-binding site is located within the 3' UTR. We show that the near-perfect miRNA site selectively triggers miR-29b destabilization through 3' trimming and restricts its spatial expression in the cerebellum. Genetic disruption of the miR-29 site within mouse Nrep results in ectopic expression of cerebellar miR-29b and impaired coordination and motor learning. Thus, we demonstrate an endogenous target-RNA-directed miRNA degradation event and its requirement for animal behavior.
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| http://dx.doi.org/10.1038/s41594-018-0032-x | DOI Listing |
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