AI Article Synopsis
- The process of forming haploid gametes from diploid cells involves the controlled release of sister chromatid cohesion during meiosis.
- Phosphorylation of the cohesin protein REC-8 by Aurora B plays a key role in this process, particularly at the onset of anaphase I in C. elegans oocytes.
- The study reveals a complex interaction among various proteins and phosphorylation mechanisms that ensure chromosomes are correctly separated during the development of egg cells.
Article Abstract
The formation of haploid gametes from diploid germ cells requires the regulated two-step release of sister chromatid cohesion (SCC) during the meiotic divisions. Here, we show that phosphorylation of cohesin subunit REC-8 by Aurora B promotes SCC release at anaphase I onset in C. elegans oocytes. Aurora B loading to chromatin displaying Haspin-mediated H3 T3 phosphorylation induces spatially restricted REC-8 phosphorylation, preventing full SCC release during anaphase I. H3 T3 phosphorylation is locally antagonized by protein phosphatase 1, which is recruited to chromosomes by HTP-1/2 and LAB-1. Mutating the N terminus of HTP-1 causes ectopic H3 T3 phosphorylation, triggering precocious SCC release without impairing earlier HTP-1 roles in homolog pairing and recombination. CDK-1 exerts temporal regulation of Aurora B recruitment, coupling REC-8 phosphorylation to oocyte maturation. Our findings elucidate a complex regulatory network that uses chromosome axis components, H3 T3 phosphorylation, and cell cycle regulators to ensure accurate chromosome segregation during oogenesis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827026 | PMC |
| http://dx.doi.org/10.1038/s41467-018-03229-5 | DOI Listing |
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