Correction of nasolabial folds wrinkle using intraoral non-ablative Er:YAG laser.

: The accentuated nasolabial folds (NLFs) is the most pronounced sign of aging. Non-ablative erbium:yttrium aluminum garnet laser (ER:YAG), Smooth mode was used for the treatment of mucosal tissue. It was reported that it is effective in facial rejuvenation. : To assess the safety and the effectiveness of intraoral ER:YAG Smooth mode laser in the treatment of NLFs wrinkle. : A total of 20 patients with different grades of NLFs wrinkle treated with 2940 nm Er:YAG laser intraorally. Six sessions were done every 2 weeks. The efficacy was assessed by two blinded dermatologists. Photographs were taken at the baseline, end of treatment and 6 months after the final session to document visible changes in NLFs wrinkle. The assessment was based on Modified Fitzpatrick Wrinkle Scale (MFWS) and by comparing the photographs. Patient's self-assessment and patient's satisfaction were used for assessment of final results and any side effects associated to treatment were observed. : There was significant reduction of the NLFs wrinkle. The MFWS was significantly improved 6 months after treatment compared to before treatment ( < 0.001). At the end of the follow-up period, there was improvement in overall appearance of the wrinkles. Patient's self -assessment and satisfaction demonstrated better cosmetic outcomes. : Intraoral Er:YAG laser is safe, painless, and effective treatment option for NLFs wrinkle.